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EC number: 201-070-7
CAS number: 77-93-0
order to cross the skin, a compound must first penetrate into the
stratum corneum and may subsequently reach the epidermis, the dermis and
the vascular network. The stratum corneum provides its greatest barrier
function against hydrophilic compounds, whereas the viable epidermis is
most resistant to penetration by highly lipophilic compounds. Substances
with a molecular weight (MG) below 100 are favourable for penetration of
the skin and substances with a MG > 500 are normally not able to
penetrate. The substance must be sufficiently soluble in water to
partition from the stratum corneum into the epidermis. Therefore if the
water solubility is below 1 mg/L, dermal uptake is likely to be low.
Additionally LogPow values between 1 and 4 favour dermal absorption
(values between 2 and 3 are optimal). Above 4, the rate of penetration
may be limited by the rate of transfer between the stratum corneum and
the epidermis, but uptake into the stratum corneum will be high. Above
6, the rate of transfer between the stratum corneum and the epidermis
will be slow and will limit absorption across the skin. Uptake into the
stratum corneum itself may be slow. Moreover vapours of substances with
vapour pressures below 100 Pa are likely to be well absorbed and the
amount absorbed dermally may be more than 10% of the amount that would
be absorbed by inhalation. If the substance is a skin irritant or
corrosive, damage to the skin surface may enhance penetration. During
the whole absorption process into the skin, the compound may be subject
case of triethyl
molecular weight is above 100 and below 500, which indicates a low
potential to penetrate the skin. Even though the water solubility of
triethyl citrate is fairly high, absorption through the lipophilic
stratum corneum is possible. The LogPow value for this substance is not
optimal (values 2-3), but still favours absorption via the skin (between
1 and 4). The amount ofsubstance,which
is absorbed following dermal exposure into the stratum corneum is
however unlikely to be transferred into the epidermis, due to its
molecular weight and LogPow. The systemic toxicity via the skin is
assumed to be low and this has been proven with the results of the acute
dermal toxicity study, which showed no mortality after dermal
application of 5000 mg/kg bw in rabbits.
order to assess the toxicological behaviour of triethyl
available experimental and predicted physico-chemical data have been
evaluated. The substance is expected to be absorbed very well. The
absorption of any metabolite of hydrolysis of the substance of interest
is, fast and complete. Concerning the absorption after exposure via
inhalation, as the chemical has low vapour pressure, it is clear, that
it is poorly available after inhalation. Given its lipophilicity (LogPow
1.17) - if absorbed - it is expected to be absorbed directly across the
respiratory tract epithelium. Triethyl citrate is expected
to be also absorbed following dermal exposure into the stratum corneum
and to a certain extent into the epidermis, due to its molecular weight
of 276.283 g/mol and its LogPow of 1.17. In addition, the systemic
toxicity via the skin is assumed to be low and this has been proven with
the results of the acute dermal toxicity study with the acute dermal
study with triethyl citrate, in which a LD50of 5000 mg/kg bw
has been obtained.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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