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Registration Dossier
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EC number: 201-070-7 | CAS number: 77-93-0
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The BCF was calculated to be 2.75 L/kg (regression-based estimate) and 2.475 L/kg (Arnot-Gobas method), respectively. [with BCFBAF v3.01 (EPIWIN software by US-EPA)]
Key value for chemical safety assessment
- BCF (aquatic species):
- 2.75 L/kg ww
Additional information
The prediction for the bioconcentration factor (BCF) of the substance triethyl citrate was done by the computer program BCFBAF v3.01 (EPIWIN software) by US-EPA. Furthermore the whole body primary biotransformation rate estimation for fish was calculated with the notation that the bio half-life normalized to 10 g fish at 15 °C. It is possible to predict the apparent metabolism half-life in fish for three different trophic levels (lower, mid and upper). Using the regression-based estimate (traditional method) a BCF of 2.75 L/kg wet-wt was calculated. Using the Arnot-Gobas method, which is based on the mechanistic first principles, the BCF results in a value of 2.475 L/kg wet-wt. Both values have been calculated based on an experimental LogPow of 1.17 [low potential for bioaccumulation according to Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP), as value is < 4]. The whole body primary biotransformation rate estimate for fish gives a half-life of 0.000246 days, whereby the rate constant (kM) for 10 g fish is designated as 100/day. This is taken into account to predict the apparent metabolism half-life in fish for the substance. For the lower trophic level a BCF of 1.29 L/kg wet-wt is calculated, whereas for the mid trophic level the BCF will result in 1.277 L/kg wet-wt and the higher trophic level gives a value of 1.201 L/kg wet-wt. Based on the results, a low potential for bioconcentration is to be expected(according to CLP Regulation 1272/2008 substances with a BCF ≥ 500 have a potential for bioconcentration in aquatic organisms).
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