Registration Dossier
Registration Dossier
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EC number: 202-426-4 | CAS number: 95-51-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated
Data source
Reference
- Reference Type:
- publication
- Title:
- Biological monitoring for industrial exposure to cyanogenic aromatic nitro and amino compounds
- Author:
- Linch, AL
- Year:
- 1 974
- Bibliographic source:
- American Industrial Hygiene Association Journal , 35: 426-432
Materials and methods
- Study type:
- other: restrospective study
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- In a 10-year study period following 1956, the clinical and laboratory evaluation of in total 187 cases of cyanosis in factory workers exposed to aromatic nitro and amino compounds was evaluated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloroaniline
- EC Number:
- 202-426-4
- EC Name:
- 2-chloroaniline
- Cas Number:
- 95-51-2
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 2-chloroaniline
- Details on test material:
- no data
Constituent 1
Method
- Subjects:
- no data
- Route of exposure:
- other: no data
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- see remarks on results
Any other information on results incl. tables
In a 10-year study period following 1956, the clinical and
laboratory evaluation of in total 187 cases of cyanosis in
factory workers exposed to aromatic nitro and amino
compounds, o-chloroaniline was ranked "most potent"
(together with the other isomers).
Urine and (secondarily) blood analyses for the TS and
methemoglobin form the basis of a control program designed
for early warning of excessive exposure. A biological
threshold limit value in urine of 1 ppm is suggested by the
author.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
