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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: endpoint study record was created to contribute to the overall results; Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Evaluation of the toxicity of substances to be assessed for biodegradability
Author:
Reynolds L, Blok J, de Morsier A, Gerike P, Wellens H, Bontinck WJ
Year:
1987
Bibliographic source:
Chemosphere 16, 2259-2277

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD 301A
Principles of method if other than guideline:
endpoint study record was created to contribute to the overall results
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroaniline
EC Number:
202-426-4
EC Name:
2-chloroaniline
Cas Number:
95-51-2
Molecular formula:
C6H6ClN
IUPAC Name:
2-chloroaniline

Test organisms

Test organisms (species):
activated sludge

Study design

Total exposure duration:
7 d

Results and discussion

Effect concentrations
Duration:
7 d
Dose descriptor:
EC50
Effect conc.:
> 27 mg/L
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Any other information on results incl. tables

endpoint study record was created to contribute to the overall results;

This study represents with an EC50 (7 d) of >27 mg o-chloroaniline/L for activated sludge the lowest detected microbial inhibition value described in the available literature.

Applicant's summary and conclusion

Executive summary:

Reynolds et al. (1987) (endpoint study record was created to contribute to the overall results);

This study represents with an EC50 (7 d) of >27 mg o-chloroaniline/L for activated sludge the lowest detected microbial inhibition value described in the available literature.