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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Although the study has been conducted according to GLP guidelines, no final report was drafted. The data summary lacks detail on: identity/composition of test material, materials and methods which makes it difficult to interpret the available data and to reproduce the study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
, no patch or other cover was used during the 4-hour application to simplify observations
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[3-(dimethylamino)propyl]acrylamide
EC Number:
223-342-4
EC Name:
N-[3-(dimethylamino)propyl]acrylamide
Cas Number:
3845-76-9
Molecular formula:
C8 H16 N2 O
IUPAC Name:
N‐[3‐(dimethylamino)propyl]prop‐2‐enamide
Details on test material:
In the study report no information is provided about the exact composition of the material tested. The DIMAPA test sample was taken at "CL1" of which it is not exactly clear where that was and what that implies for substance identity. Based on the identifyer "DIMAPA" with productnumber "A2699" it may be assumed that the test material is similar enough to the on-site isolated intermediate registered here.

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
open
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
Animals received a single dermal dose which was washed off after 4 hours.
Observation period:
Observations took place at t= 30-60 min., 24h, 48h, 72h and 7d.
Number of animals:
3, 1 male, 2 females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: all
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
other: all
Score:
0
Max. score:
0
Other effects:
Corrosion, desquamation and atrophy were also scored as being 0 (zero).

Any other information on results incl. tables

 

             animal 1 (male)

              animal 2 (female)       animal 3 (female)       
   30 -60mins.  24h  48h  72h  7d 30 -60mins.  24h   48h  72h  7d  30 -60mins.  24h  48h  72h  7d

 erythema

  0 0   0  0  0  0  0  0  0  0  0  0  0  0  0
 edema  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
 corrosion 0   0  0  0  0  0  0  0  0  0  0  0  0  0  0
 desquamation 0   0  0  0  0  0  0  0  0  0  0  0  0  0  0
 atrophy  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Based on a finding of 0/4 possible points for both erythema and edema, the test material was considered to be non irritating.