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EC number: 926-000-9
CAS number: 1180524-77-9
Table 1: Summary of the LLNA/IMDS results with M 530 (means of 6 animals
weight of draining lymph nodes
cell count in draining lymph nodes
Ear swelling in 0.01 mm on day 4 (index)
Ear weight in mg / 8 mm diameter punch on day 4 (index)
* statistically significant increase
The body weights of the animals were not affected by any treatment.
The test item was investigated in the modified local lymph node
assay (LLNA-IMDS) on female mice according to OECD TG 429.
Concentrations of 0 (vehicle control), 10 %, 30 % and 100 % formulated
in dimethylformamide were tested. Compared to vehicle treated animals
there was a clear increase regarding the cell counts (index of 1.53 %),
which is statistical significant. The "positive level" of index 1.4 for
the cell counts, has been exceeded in this dose group. The EC 1.4 value
calculated for this test item is 80.22 %. In accordance with the
classification proposed in the Technical Report No. 78 of the ECETOC
(2003) this value corresponds to a weak skin sensitiser.
In summary, these results show that the test item has a weak
sensitising potential in mice after dermal application of a 100 %
concentration. The concentration of 30 % turned out to be the NOEL for
the parameters investigated in this study.
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