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EC number: 926-000-9
CAS number: 1180524-77-9
The remarks on the toxicokinetics of
and formaldehyde), propoxylated are based on physicochemical properties
of the compound and on toxicological data. Experimental toxicokinetic
studies were not performed.
The substance is a slightly yellowish, viscous liquid. (Neuland,
2012) with a low vapour pressure under normal ambient conditions (0.011
Pa at 20 °C, Fonseca, 2012). Inhalation exposure via vapour is therefore
not to be expected. Absorption of the substance via skin or mucosa could
not be ruled out due to a log Pow of 1.4 at 25 °C (Garcia-Sanchez, 2012),
whereas water solubility (0.063 and 0.566 g/L at 20 °C, Neuland,
2012) and the quite high average molecular weight of the substance (see
IUCLID chapter 1.1) seem to point to a low ability to be absorbed. In
fact, no indications for systemic availability could be observed after
acute oral or dermal exposure to the substance as there were no
toxicological effects at all reported (OECD TG 423 and 402, both
Gillissen, 2012). Some indications for systemic availability give the
oral repeated dose toxicity study where only for male rats of the high
dose group (1000 mg/kg bw) slight effects on thyroids were observed
(OECD TG 407, Popp, 2012).
2-(2-hydroxyethylamino)ethanol and formaldehyde), propoxylated proved as
skin sensitizer in a Local Lymph Node Assay (Vohr, 2012), therefore at
least some dermal bioavailability after skin contact is expected.
There are indications from the in vitro assays for
irritating/corrosive properties of the substance which might influence
skin or mucosa barrier function and thus systemic availability.
Deducing from the repeated dose toxicity study where no
distinct substance-related adverse effects except thyroid findings were
reported and from the above specified log Pow, no potential for
accumulation is to be expected for the substance.
Based on the results of in vitro genotoxicity tests (negative with
and without metabolic activation in Ames test, Nern, 2012; HPRT test,
Wollny, 2012; Micronucleus test, Nern, 2012) it is concluded that
DNA-reactive metabolites of4-[2-(4-hydroxyphenyl)propan-2-yl]phenol,
2-(2-hydroxyethylamino)ethanol and formaldehyde), propoxylatedwill
most probably not be generated in mammals in the course of hepatic
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