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EC number: 926-000-9
CAS number: 1180524-77-9
In a repeated dose oral toxicity study in rats (Wistar, OECD TG 407),
the substance was adimistered via gavage to 5 rats/sex/dose at 0, 100,
500, 1000 mg/kg bw in PEG 400 for 4 weeks. Up to and including 1000
mg/kg bw no mortality occured. The behavior and clinical appearance of
the rats were not influenced by the treatment up to and including 1000
mg/kg in both sexes. The body weight gain, the food, water intake,
clinical chemistry and organ weights were not affected up to and
including 1000 mg/kg in males and females. The results from Functional
Observational Battery (FOB) measurements in males and females receiving
up to and including 1000 mg/kg bw did not differ from the control
animals. Motor and Locomotor Activity(MA/LMA) tests did not
indicate neurotoxicity up to and including 1000 mg/kg.
Adverse findings were observed at 1000 mg/kg b.w. and consisted of
a decrease of erythrocytes, hemoblobin and hematocrit in
males and females and histopathological findings in the thyroid gland of
Therefore, under the condition of the present study, the NOAEL
(no-observed-adverse-effect-level) for M 530 after 4-week daily oral
treatment by gavage is 500 mg/kg b.w. for male and female rats.
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