Registration Dossier
Registration Dossier
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EC number: 270-984-6 | CAS number: 68512-62-9 A complex residuum from the vacuum distillation of the residuum from the atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: RELIBLE SUMMARY REPORT
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- IUCLID DATASET SUBSTANCE ID:68512-62-9
- Author:
- EUROPEAN COMMISSION - EUROPEAN CHEMICALS BUREAU
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET SUBSTANCE ID:68512-62-9 PG 41
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DRAIZE TEST
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Residues (petroleum), steam-cracked
- EC Number:
- 265-193-8
- EC Name:
- Residues (petroleum), steam-cracked
- Cas Number:
- 64742-90-1
- IUPAC Name:
- 64742-90-1
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- other: only one eye was treated
- Duration of treatment / exposure:
- 24H
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- >= 2 - <= 9
- Reversibility:
- not specified
Any other information on results incl. tables
Conjunctival redness was noted in all animals, but there was no evidence of
corneal or iridial damage. At the 24–hour point, conjunctival scores ranged from 2
to 9 out of a maximum of 110, with an average of 5.0. The scores declined
thereafter and all irritation had subsided within 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- slightly irritating
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