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EC number: 270-984-6 | CAS number: 68512-62-9 A complex residuum from the vacuum distillation of the residuum from the atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: RELIABLE SUMMARY STUDY.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- IUCLID DATASET SUBSTANCE ID:68512-62-9
- Author:
- EUROPEAN CHEMICALS BUREAU
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET SUBSTANCE ID:68512-62-9 PG 73
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- procedure as detailed in paper by Feuston M.H.
Developmental toxicity of clarified slurry oil applied dermally to rats, Toxicol. Ind. Health,vol. 5, p. 587, 1989. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Clarified oils (petroleum), catalytic cracked
- EC Number:
- 265-064-6
- EC Name:
- Clarified oils (petroleum), catalytic cracked
- Cas Number:
- 64741-62-4
- IUPAC Name:
- 64741-62-4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- dermal
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 19 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
five tests groups:4, 8, 30, 125 and 250 mg/kg/day.
Basis:
no data
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 4 mg/kg bw/day
- Based on:
- no data
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 4 mg/kg bw/day
- Based on:
- no data
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
SIGNS OF MATERNAL TOXICITY, seen at doses as low as 8 mg/kg/day, included VAGINAL BLEEDING, DECREASED BODYWEIGHT GAIN, REDUCED FOOD CONSUMPTION, DEATH, INCREASED RELATIVE LIVER WEIGHTS, ATROPHY OF THE THYMUS, and ABERRANT SERUM CHEMISTRY. The number of FOETAL RESORPTIONS/DEATHS was MARKEDLY INCREASED, and the number of VIABLE OFFSPRING DECREASED, by CCCO exposure at doses of 30 mg/kg/day and greater. THE GROUP RECEIVING 250 mg/kg/day CARRIED NO VIABLE OFFSPRING. Foetuses from pregnant females exposed to CCCO at doses greater than 8 mg/kg/day were smaller than those from the negative control and 4 mg/kg/day groups, and their skeletons showed decreased ossification. ABNORMAL EXTERNAL DEVELOPMENT and VISCERAL DEVELOPMENT WERE OBSERVED IN LIVING AND DEAD FOETUSES EXPOSED IN UTERO to CCCO at DOSE LEVELS of 8 mg/kg/day and greater.
Applicant's summary and conclusion
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