Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

Toxicity to birds

Administrative data

Endpoint:

long-term toxicity to birds: reproduction test

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

January 1981-August 1981

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The study was conducted under GLP and under the proposed guidelines of the United States Environmental Protection Agency (E.P.A.) § 163:71-4 Avian Reproduction and published in the Federal Register 10 July 1978, Part II, pages 29729- 29731. The study is well documented and it can be considered reliable without restrictions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPP 71-4 (Avian Reproduction Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

EC Number:

932-389-6

Molecular formula:

C23H19ClF3NO3

IUPAC Name:

Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

Applicant's summary and conclusion

Conclusions:

The study is considered to be reliable without restrictions.

Executive summary:

The study was designed to determine the effect of dietary administration of cyhalothrin on reproduction in the Mallard duck.

The protocol was based on the proposed guidelines of the United States Environmental Protection Agency (E.P.A.) § 163:71-4 Avian Reproduction and published in the Federal Register 10 July 1978, Part II, pages 29729- 29731.

Under the conditions of this study there was no evidence that dietary administration of cyhalothrin at dose levels of 5 ppm and 50 ppm had any adverse effects on reproduction in the Mallard duck.

The results are summarized below.

Adults:

Mean analysed concentrations of cyhalothrin in avian diet were within 10% of nominal values. Concentrations of cyhalothrin in blended diet prepared to check homogeneity indicated a satisfactory mix of test compound in the diet. The stability of cyhalothrin in diet at ambient temperature in the animal room was confirmed during storage for 18 days.

The mortalities which occurred could not be considered to be related to treatment with cyhalothrin and were in most cases the result of fighting between the male birds in a pen. Bird health was generally good, the majority of observations made being related to the effects of fighting between the birds in a pen. This is unavoidable with group housing of Mallard ducks.

Group mean bodyweights and bodyweight changes were within normal limits and no treatment-related, statistically significant differences were found.

Food consumption was within normal limits and no statistically significant differences between treatments were found.

Evidence of bullying was noted in a large number of sporadic mortalities. These and other abnormalities which were observed in the sporadic mortalities were not considered to be related to treatment with cyhalothrin.

Eggs:

Over weeks 1 to 6 and 7 to 12 birds given cyhalothrin at50ppm produced significantly fewer eggs than the controlP<O.05).This is, however, probably not biologically significant since the total number of eggs laid for Group C (Cyhalothrin50ppm) was high (1419) in comparison with the control data (ranging between 877 and 1027 eggs per group) obtained at the Huntingdon Research Centre in 1980. Broken and cracked eggs were within normal limits and no treatment-related differences were found.

There were no significant differences in mean egg weights between the groups. The egg mass (total weight of eggs laid) was significantly lower for Group C (Cyhalothrin50ppm) than for the control(P<O.OS).However, since this is dependent on the number of eggs laid it is unlikely to be biologically significant.

Egg shell thickness was within normal limits and there were no treatment-related differences.

Incubation and candling:

Group B (Cyhalothrin 5 ppm) had a significantly lower proportion of infertile eggs than the control. The proportions for all groups were within normal limits.

No statistically significant differences between treatments were found and the proportions of early embryonic mortalities were within normal limits. About Late embryonic mortalities, the proportions were within normal limits and there were no treatment-related differences.

The proportions of ducklings which hatched were not significantly different between treatments and were within normal limits.

Ducklings:

No treatment-related abnormalities were noted about bird health. The mortalities which occurred were not considered to be

treatment-related. The percentages of birds surviving to 14 days were within normal limits and no statistically significant differences were found. Bodyweights at hatching and at 14 days were within normal limits and no statistically significant differences between treatments were found.

As per gross macroscopic post mortem examination no treatment-related abnormalities were found.