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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Screening test only, gives some indication of toxicity but exposure was static, methods described in an earlier publication Smyth et al. Am. In. Hyg. Assoc. J. 23:95-107, 1962. This study is also reported in Patty 2001.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Aliphatic alcohols (Monohydric alcohols).
Author:
Bevan C
Year:
2001
Bibliographic source:
Patty's Toxicology. John Wiley & Sons - online.
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30(5): 470-476

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth et al, 1962
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
icosanol (mixed isomers)

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male/female

Administration / exposure

Duration of exposure:
8 h
No. of animals per sex per dose:
6

Results and discussion

Any other information on results incl. tables

All rats survived this 8 hour static exposure to the concentrated vapours. LC50 > saturated vapour concentration.

Applicant's summary and conclusion