Registration Dossier
Registration Dossier
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EC number: 942-135-6 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Screening test only, gives some indication of toxicity but exposure was static, methods described in an earlier publication Smyth et al. Am. In. Hyg. Assoc. J. 23:95-107, 1962. This study is also reported in Patty 2001.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Aliphatic alcohols (Monohydric alcohols).
- Author:
- Bevan C
- Year:
- 2 001
- Bibliographic source:
- Patty's Toxicology. John Wiley & Sons - online.
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30(5): 470-476
Materials and methods
- Principles of method if other than guideline:
- Method: other: Smyth et al, 1962
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Icosanol - mixed isomers
- IUPAC Name:
- Icosanol - mixed isomers
- Details on test material:
- icosanol (mixed isomers)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male/female
Administration / exposure
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6
Results and discussion
Any other information on results incl. tables
All rats survived this 8 hour static exposure to the concentrated vapours. LC50 > saturated vapour concentration.
Applicant's summary and conclusion
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