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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Screening test only, gives some indication of toxicity but exposure was static, methods described in an earlier publication Smyth et al. Am. In. Hyg. Assoc. J. 23:95-107, 1962. This study is also reported in Patty 2001.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Aliphatic alcohols (Monohydric alcohols).
Author:
Bevan C
Year:
2001
Bibliographic source:
Patty's Toxicology. John Wiley & Sons - online.
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30(5): 470-476

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth et al, 1962
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Icosanol - mixed isomers
IUPAC Name:
Icosanol - mixed isomers
Details on test material:
icosanol (mixed isomers)

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male/female

Administration / exposure

Duration of exposure:
8 h
No. of animals per sex per dose:
6

Results and discussion

Any other information on results incl. tables

All rats survived this 8 hour static exposure to the concentrated vapours. LC50 > saturated vapour concentration.

Applicant's summary and conclusion