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EC number: 942-135-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Alcohols, C20-30 (even numbered), is a UVCB substance that comprises several linear long chain alcohols, predominantly tetracosan-1-ol (C24), hexacosan-1-ol (C26), and octacosan-1-ol (C28). Together, these substances make up approximately 70% of the composition of Alcohols, C20-30 (even numbered). Other constituents include, to a much lesser extent, secondary long chain alcohols and complex mixtures of long chain carboxylate esters. On this basis, study data, where available, for each of the long chain alcohol constituents has been evaluated and considered together; this is consistent with the Category approach applied for Long Chain Alcohols (LCA) under REACH. In a conservative approach the most sensitive study result from the constituents of the LCA category have been identified and used to address the endpoint in question.
In a reliable (Klimisch 1) OECD 406 GLP compliant study the skin sensitising potential of octadecan-1-ol has been assessed. Octadecan-1-ol data in this instance has been used provide read-across data for the sensitisation endpoint of tetracosan-1-ol, hexacosan-1-ol, and octacosan-1-ol. In this study octadecan-1-ol was reported to not be a skin sensitiser when tested using the Magnusson and Kligman guinea pig maximization procedure. A second reliable (Klimish 1) study following OECD 406 and EU method B.6 guidelines and under GLP compliance examined a mixture of icosan-1-ol and docosan-1-ol in female Dunkin-Hartley guinea pigs. The mixture did not elicit a sensitization response when given a dermal injection of 5% test material concentration in the first week, 75% test material concentration in the second week with a topical application of 10% concentration two weeks after the higher injection. Consequently in line with the read-across justification included, Alcohols, C20-30 (even numbered), is not considered to be sensitising.
Migrated from Short description of key information:
The key study for sensitisation was a reliable (Klimisch 1) OECD 406 study with octadecan-1-ol. In this study the test substance was reported to be non-sensitising.
A reliable (Klimish 1) study following OECD 406 and EU method B.6 guidelines and under GLP compliance examined a mixture of icosan-1-ol and docosan-1-ol in female Dunkin-Hartley guinea pigs and found to mixture to be not-sensitising .
Justification for selection of skin sensitisation endpoint:
This reliable Klimisch 1 study follows EU guidelines and is GLP compliant. Octadecan-1-ol was not reported a skin sensitiser when tested using the Magnusson and Kligman guinea pig maximization procedure.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
These findings do not warrant the classification of Alcohols, C20-30 (even numbered),as a sensitiser under the new Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP) and under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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