Registration Dossier
Registration Dossier
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EC number: 405-490-3 | CAS number: 613-62-7 BENZYL-2-NAPHTHYLETHER; BETA-NAPHTHYLBENZYLETHER (BON); BNE; BON; NIPAFAX BNE; SENSLON-50; ZO-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study submitted in the ELINCS notification dossier.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2-(phenylmethoxy)naphthalene
- EC Number:
- 405-490-3
- EC Name:
- 2-(phenylmethoxy)naphthalene
- Cas Number:
- 613-62-7
- Molecular formula:
- C17H14O
- IUPAC Name:
- 2-(benzyloxy)naphthalene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- maize oil
- Duration of treatment / exposure:
- 24 or 48 hours after treatment
- Post exposure period:
- 24 or 48 hr for the highest dose. Only 24 h for the others.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
200 mg/kg
Basis:
no data
- Remarks:
- Doses / Concentrations:
670 mg/kg
Basis:
no data
- Remarks:
- Doses / Concentrations:
2000 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- 5
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- at 2000 mg/kg (reduced spontaneous activity, reversible within 24 h
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- 24h :
200 mg/kg PCE/NCE: 1000/644
670 mg/kg PCE/NCE: 1000/687
2000 mg/kg PCE/NCE: 1000/663
48 h:
2000 mg/kg PCE/NCE: 1000/643
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The substance doesn't induce micronucleus in the mouse - Executive summary:
The micronucleus test has been performed in mouse (males and females) with the substance by ip injection of 200 to 2000 mg/kg. The micronucleus were determined at 24 or 48 h after treament for the highest tested dose and at 24 h only for 200 and 670 mg/kg. Sign of toxicity were observed at 2000 mg/kg.
In the conditions of this test, the substance didn't induce positive results.
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