Registration Dossier
Registration Dossier
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EC number: 405-490-3 | CAS number: 613-62-7 BENZYL-2-NAPHTHYLETHER; BETA-NAPHTHYLBENZYLETHER (BON); BNE; BON; NIPAFAX BNE; SENSLON-50; ZO-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 427 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
No data is available by dermal or inhalation route.
A 28 days study was also performed and the NOAEL is lower than in the 90-d study (30 mg/kg/day and 427 mg/kg/day, respectively). Differences in the study design can maybe explain this observation: the subacute study was performed by gavage in Sprague-Dawley rats and the subchronic study was carried out with a dietary exposure and using Wistar rats. However, the slight hepatotoxicity is a common effect observed in both cases.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; other: all gross lesions and masses
Justification for classification or non-classification
No classification regarding repeated toxicity has been defined for this substance in the annex VI. This is not necessary based on the available data.
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