Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study submitted in the ELINCS notification dossier.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(phenylmethoxy)naphthalene
EC Number:
405-490-3
EC Name:
2-(phenylmethoxy)naphthalene
Cas Number:
613-62-7
Molecular formula:
C17H14O
IUPAC Name:
2-(benzyloxy)naphthalene

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Vehicle:
water
Duration of treatment / exposure:
4 h
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24, 48, 72h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24, 48, 72h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24, 48, 72h
Score:
0
Irritation parameter:
erythema score
Basis:
other: all animals
Time point:
other: before 24 h
Score:
1
Max. score:
1
Reversibility:
other: within 24 h
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24, 48, 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24, 48, 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24, 48, 72h
Score:
0
Irritation parameter:
edema score
Basis:
other: all animals
Time point:
other: Before 24 h
Score:
1
Max. score:
1
Reversibility:
other: within 24 h

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is not irritating for the skin.
Executive summary:

A skin irritation study has been performed in the rabbit with the substance according to the guideline B4.

Erythema and edema of grade 1 were observed within the first 24 h, at 24, 48 and 72, the grade for both effects was 0 in all animals.

So the substance is not irritating on the rabbit skin.

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