Registration Dossier
Registration Dossier
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EC number: 405-490-3 | CAS number: 613-62-7 BENZYL-2-NAPHTHYLETHER; BETA-NAPHTHYLBENZYLETHER (BON); BNE; BON; NIPAFAX BNE; SENSLON-50; ZO-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study submitted in the ELINCS notification dossier.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(phenylmethoxy)naphthalene
- EC Number:
- 405-490-3
- EC Name:
- 2-(phenylmethoxy)naphthalene
- Cas Number:
- 613-62-7
- Molecular formula:
- C17H14O
- IUPAC Name:
- 2-(benzyloxy)naphthalene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: all animals
- Time point:
- other: before 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- other: within 24 h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: all animals
- Time point:
- other: Before 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- other: within 24 h
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not irritating for the skin.
- Executive summary:
A skin irritation study has been performed in the rabbit with the substance according to the guideline B4.
Erythema and edema of grade 1 were observed within the first 24 h, at 24, 48 and 72, the grade for both effects was 0 in all animals.
So the substance is not irritating on the rabbit skin.
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