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EC number: 923-400-5
CAS number: -
The objective of this study was to
evaluate the potential toxicity of the test item following a single
dermal application to rats.
This study was conducted in compliance
with the principles of Good Laboratory Practice and accoding to OECD
The test item was applied in its
original form to the skin of five female then five male Sprague-Dawley
rats at the dose-level of 2000 mg/kg. The application site was covered
by a semi-occlusive dressing for 24 hours.
Each animal was observed at least once
a day for mortality and clinical signs for 15 days. From day 2, local
reactions at the treatment site were also noted. Body weight was
recorded on day 1 and then on days 8 and 15.
On completion of the observation
period, the animals were sacrificed and a full macroscopic post-mortem
examination was performed. Macroscopic lesions were preserved.
There were no unscheduled deaths
during the study and no clinical signs indicative of systemic toxicity
were observed in any animal.
No cutaneous reactions were observed
in males.Very slight erythema was recorded at the application site of
all females during from day 2 until days 3, 4 or 5. Lower
body weight gain was recorded in 2/5
females and 4/5 males. There were no test item-related
The dermal LD50of the test
item was higher than 2000 mg/kg in rats.
Therefore, the test item is not
classified as toxic by dermal route according to the criteria of
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