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Dodecane-12-lactam, manufacturing of, by-products from, distillation residues has been shown to be no toxic to fish and algae and harmful to daphnia in several acute studies (fish: 96 h LC50-96h > 100 mg/L (nominal value); algae: EC50-72h > 100 mg/L (nominal value): daphnids: EC50-48h = 33.67 mg/L (measured concentration).


As no long-term toxicity studies are available (except algae study), the PNEC can be determined using the lowest short-term result by applying an uncertainty factor of 1000. The resulting PNEC would be 33.67 µg/L.