Registration Dossier
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EC number: 234-682-8 | CAS number: 12023-53-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 May 2010 - 21 July 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to official EC and OECD test guidelines, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report Date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. certificate)
- Test type:
- acute toxic class method
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD "SD"
- Sex:
- female
- Details on test animals and environmental conditions:
- The animals were allocated without conscious bias to cages within the treatment groups.
They were housed in groups of three rats of the same sex, in solid bottomed polycarbonate
cages with a stainless steel mesh lid. Each cage contained a quantity of autoclaved wood
flake bedding. Cages, food hoppers, water bottles and bedding were changed at appropriate
intervals.
Each animal was assigned an alpha-numeric code and identified uniquely within the study by
tail marking. Each cage label was colour-coded and was identified uniquely with the study
number, dose level and animal mark.
The animal room was kept at positive pressure with respect to the outside by its own supply
of filtered fresh air, which was passed to atmosphere and not re-circulated. The temperature
and relative humidity controls were set to maintain the range of 19 to 23°C and 40 to 70%
respectively. Any minor deviations from these ranges would not have had an adverse effect
on the animals and would not affect the integrity or validity of the study. Artificial lighting
was controlled to give a cycle of 12 hours continuous light and 12 hours continuous dark per
24 hours.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% (w/v) aqueous methylcellulose
- Doses:
- 300 and 2000 mg/kg
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- The test substance was formulated at concentrations of 30 and 200 mg/mL in the vehicle and
administered at a volume of 10 mL/kg bodyweight.
The test substance formulations were prepared on the day of dosing.
The animals were allowed free access to a standard rodent diet (Rat and Mouse No. 1
Maintenance Diet), except for overnight prior to and approximately four hours after dosing.
This diet contained no added antibiotic or other chemotherapeutic or prophylactic agent.
Potable water taken from the public supply was freely available via polycarbonate bottles
fitted with sipper tubes.
During the acclimatisation and study periods, each cage of animals was provided with a soft
white untreated chew block and a plastic shelter for environmental enrichment.
The absorption of the test substance was not determined.
Determination of the homogeneity, stability and purity of the test substance or test substance
formulations were not undertaken as part of this study.
Detailed records of test substance usage were maintained. The amount of test substance
necessary to prepare the formulations and the amount actually used were determined on each
occasion. The difference between these amounts was checked before the formulations were
dispensed.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- Clinical signs of reaction to treatment comprised faeces abnormal colour (black) seen in all
females dosed at 300 mg/kg and three females (A7, A8 and A9) dosed at 2000 mg/kg. These
signs were first noted approximately thirty minutes or two hours after dosing, and had
resolved by Day 2. - Body weight:
- A low bodyweight gain was recorded between Days 8 – 15 for two females (A1, A2) dosed at
300 mg/kg and three females (A9, A10, A12) dosed at 2000 mg/kg.
All remaining animals were considered to have achieved satisfactory bodyweight gains
throughout the study. - Gross pathology:
- No abnormalities were noted in any animal at the macroscopic examination at study
termination on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute median lethal oral dose (LD50) to rats of Ferrophosphorus (Fe3P) was
demonstrated to be greater than 2000 mg/kg bodyweight.
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