Registration Dossier
Registration Dossier
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EC number: 254-075-1 | CAS number: 38668-48-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was performed prior to the implementation of GLP and OECD Guidelines, but meets the principles of an acute inhalation toxicity study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- 8h inhalation exposure to a saturated test item atmosphere
according to Smyth et al.: Am. Ind. Hyg. Ass. J., 23, 95-107 (1944) - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- EC Number:
- 254-075-1
- EC Name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- Cas Number:
- 38668-48-3
- Molecular formula:
- C13H21NO2
- IUPAC Name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- Details on test material:
- Name of the test substance used in the study report: Diisopropanol-p-toluidin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- mean body weight at study start: 203 g
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Two groups of 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- saturated atmophere at 20°C
- No. of animals per sex per dose:
- 3 rats (total of 12 rats tested in two subsequent experiments)
- Control animals:
- no
- Details on study design:
- - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
- observation period: 7 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- other: saturated atmosphere
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- none
- Clinical signs:
- other: no abnormality detected
- Gross pathology:
- no abnormality detected
Applicant's summary and conclusion
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