Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Parent fertility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 987
- Bibliographic source:
- Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,29,1987
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY7000000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,29,1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitroaniline
- EC Number:
- 202-810-1
- EC Name:
- 4-nitroaniline
- Cas Number:
- 100-01-6
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 4-nitroaniline
- Details on test material:
- - Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6-13 day(s) after conception
- Control animals:
- not specified
Examinations
- Litter observations:
- litter size (e.g. # fetuses per litter; measured before birth)
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- LOEL
- Effect level:
- 9 600 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Results: F1 generation
Details on results (F1)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Reproductive toxicity LOEL (low observed effect level) of 4-nitroaniline was observed at dose concentration of 9600 mg/kg. in a 6-13 day(s) after conception to female mouse by the oral route. There was reduced weight gain observed in new borns.
- Executive summary:
Reproductive toxicity LOEL (low observed effect level) of 4-nitroaniline was observed at dose concentration of 9600 mg/kg. in a 6-13 day(s) after conception to female mouse by the oral route. There was reduced weight gain observed in new borns.
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