Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY7000000
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 012
- Bibliographic source:
- RTECS ;HPV303 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Mononitroanilines Category.pdf http://www.epa.gov/HPV/pubs/summaries/mntranlc/c14391tc.htm Volume(issue)/page/year: -,-,2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitroaniline
- EC Number:
- 202-810-1
- EC Name:
- 4-nitroaniline
- Cas Number:
- 100-01-6
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 4-nitroaniline
- Details on test material:
- - Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6-19 day(s) after conception
- Control animals:
- not specified
Results and discussion
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- LOEL
- Effect level:
- 3 500 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: fetotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Mammal rat foetus 6-19 day(s) after conception show Developmental Abnormalities - musculoskeletal system if subatance 4-nitroaniline reaches a LOEL (lowest observed effect concentration) concentration of 3500 mg/kg.
- Executive summary:
Mammal rat foetus 6-19 day(s) after conception show Developmental Abnormalities - musculoskeletal system if subatance 4-nitroaniline reaches at LOEL (lowest observed effect concentration) concentration 3500 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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