Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY7000000
- Author:
- National Technical Information Service
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0572389
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4-nitroaniline
- EC Number:
- 202-810-1
- EC Name:
- 4-nitroaniline
- Cas Number:
- 100-01-6
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 4-nitroaniline
- Reference substance name:
- 100-01- 6
- IUPAC Name:
- 100-01- 6
- Details on test material:
- - Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
4-nitroaniline when administered onto the skin of guinea pig in the standard acute toxicity test by the dermal route gave a LD50 value of >500 mg/kg body weight. This result indicates that 4-nitroaniline is acutely toxic to guinea pig by the dermal route according to Toxicity Category III.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4-nitroaniline when administered onto the skin of guinea pig in the standard acute toxicity test by the dermal route gave a LD50 value of >500 mg/kg body weight. This result indicates that 4-nitroaniline is acutely toxic to guinea pig by the dermal route in Toxicity Category III.
- Executive summary:
4-nitroaniline when administered onto the skin of guinea pig in the standard acute toxicity test by the dermal route gave a LD50 value of >500 mg/kg body weight. This result indicates that 4-nitroaniline is acutely toxic to guinea pig by the dermal route in Toxicity Category III.
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