Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity to fish:-
The 48 hrs. LC50 value of 4-nitroaniline in fish (Leuciscus idus) was examined to be 35 mg/l. Considering this LC50 value of 4-nitroaniline, it can be concluded that this chemical will exhibit short term toxicity to fish in aquatic chronic 3 category as per the C & L criteria set by EU.
Long term toxicity to fish:-
According to annex IX of column I,Long-term toxicity testing on fish need not to be conducted as it is already provided as part of Annex VIII requirements.Therefore this study was considered waived.
Short-term toxicity to aquatic invertebrates:-
Lethal concentration (LC50) value for 4-nitroaniline to invertebrate Daphnia magna in a 24 hr study on the effect basis of mortality for 4-nitroaniline was estimated to be 24 mg/L. Based upon this value it can be concluded that 4-nitroaniline shall exhibit toxicity to aquatic invertebrates like Daphnia in aquatic chronic 3 category as per the C & L criteria.
Long-term toxicity to aquatic invertebrates:-
According to annex IX of column I;Long-term toxicity testing on invertebrate (species : Daphnia) need not to be conducted as it is already provided as a part of Annex VII requirements.
Toxicity to aquatic algae and cyanobacteria :-
Toxicity to aquatic algae Chlorococcales on the basis of Physiology effect examined for 24 hrs. as 50% effect concentration (EC50) : 68 mg/l . Considering this EC50 value of 4-nitroaniline, it can be assumed that this chemical will exhibit toxicity to aquatic algae in aquatic chronic 3 category as per the C & L criteria.
Toxicity to microorganisms:-
Inhibition concentration to 50% of test organisms Tetrahymena pyriformis (Ciliate) was examined at dose concentration of 10.14 mg/L (IC50). Measurement of population growth rate was observed at 10.14 mg/L.This value indicates that 4-nitroaniline will exhibit toxicity to microorganism
in aquatic chronic 3 category as per the C & L criteria set by EU.
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