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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Test substance 4-nitroaniline was non irritating to skin and eyes of rabbit.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from an authoritative source and the process of obtaining the full study report from the data owner is on-going.
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
data obtained from Actor database
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: not irritating to skin
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to Aggregated Computational Toxicology Resource (ACToR) database; 4-nitroaniline was not found to be irritating to the skin of rabbit.
Executive summary:

According to Aggregated Computational Toxicology Resource (ACToR) database; 4-nitroaniline was not found to be irritating to the skin of rabbit.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from an authoritative source and the process of obtaining the reprint that shall give legitimate access to the study is on-going.
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
data obtained from Actor database
GLP compliance:
not specified
Species:
other: no data
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: Is mildly irritating to the eyes and may cause some corneal damage.
Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
4-nitroaniline is mildly irritating to the eyes and may cause some corneal damage. However, the slightly irritating effect to the eye is not considered substantial enough to classify 4-nitroaniline as an eye irritant.
Executive summary:

4-nitroaniline is mildly irritating to the eyes and may cause some corneal damage. However, the slightly irritating effect to the eye is not considered substantial enough to classify 4-nitroaniline as an eye irritant.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:-

According to ACToR database 4-nitroaniline not irritating to skin of rabbit.

Eye irritation:-

In-vivo studies on rabbits indicates that 4-nitroaniline was not irritating to eyes of rabbit.


Justification for selection of skin irritation / corrosion endpoint:
According to Aggregated Computational Toxicology Resource (ACToR) database; 4-nitroaniline was not found to be irritating to the skin of rabbit.

Justification for selection of eye irritation endpoint:
4-nitroaniline is mildly irritating to the eyes and may cause some corneal damage. However, the slightly irritating effect to the eye is not considered substantial enough to classify 4-nitroaniline as an eye irritant.

Justification for classification or non-classification

The studies mentioned in the irrtation end point of eye and skin indicate that the substance will not have irritation properties for 4 -nitroaniline and thus will not be considered for classification.