Registration Dossier
Registration Dossier
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EC number: 225-059-1 | CAS number: 4635-59-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound 4-chlorobutyryl chloride: With high probability acutely not harmful to fish after pH-adjustment.
Hydrolysis product 4-chlorobutyric acid: With high probability acutely not harmful to fish after pH-adjustment (depending on the results of the parent compound).
Hydrolysis product HCl: Acutely toxic to fish (pH dependent).
Key value for chemical safety assessment
Additional information
Parent compound 4 -chlorobutyryl chloride and hydrolysis product 4 -chlorobutyric acid:
The acute fish toxicity of 4 -chlorobutyryl chloride (4635 -59 -0) was determined with Leuciscus idus according to German Industrial Standard DIN 38 412, part 15. 4 -chlorobutyryl chloride hydrolyses rapidly, therefore the fish were mainly exposed to its hydrolysis products 4 -chlorobutyric acid and hydrochloric acid. The obtained LC50 (96-h) was 68.12 mg/L (geometric mean). When tested under neutralized conditions (pH-adjustment), the LC50 was > 100 mg/L (BASF AG, 1987; 10F0529/875205). Based on the mentioned study the test substance 4 -chlorobutyryl chloride and its hydrolysis product 4 -chlorobutyric acid are assessed to be with high probability acutely not harmful to fish.
Hydrolysis product hydrochloric acid (HCl):
HCl was tested in a semi-static acute toxicity test according to OECD 203 with Cyprinus carpio. The 96-h LC50 was 4.92 mg/L (acid equivalent to pH 4.3; OECD, 2002).
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