Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.051 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.506 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.005 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
20 mg/L
Assessment factor:
50
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.43 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.043 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.056 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Additional information

Effect values of the hydrolysis product HCl (7647 -01 -0) were not considered in the ecotoxicological evaluation of the substance since the observed toxicity was not due to intrinsic properties of the molecule, but is due to pH effects.

Conclusion on classification

Results are available for fish (4-chlorobutyryl chloride, 96 -h LC50 > 100 mg/L; neutralized), aquatic invertebrates (isobutyric acid, 48 -h EC50 = 51.25 mg/L) and algae (based on geometric mean of propionic acid, isobutyric acid and 2 -ethylhexanoic acid, 72 -h ErC50 = 50.6 mg/L, 72 -h NOEC = 32.5 mg/L). Effect values of the hydrolysis product HCl (7647 -01 -0) were not considered in the ecotoxicological evaluation of the substance since the observed toxicity was not due to intrinsic properties of the molecule, but is due to pH effects.

Official classification regarding environmental hazards:

Aquatic compartment

In accordance with Regulation (EC) No 1272/2008 Annex VI Table 3.1 or Table 3.2, 4 -chlorobutyryl chloride: no data found.

In accordance with Regulation (EC) No. 1272/2008 Annex VI Table 3.1 or Table 3.2, 4 -chlorobutyric acid: no data found.

 

 

Self-classification

Aquatic compartment

Following DSD/DPD, the parent compound 4 -chlorobutyryl chloride is not to be classified as dangerous for the environment. The lowest LC50/EC50 value is 50.6 mg/L (geometric mean), but the substance is readily biodegradable and the log Pow is < 3 (no experimentally determined BCF).

Following CLP (GHS-EU), the substance is not to be classified as acutely hazardous to the aquatic environment, since the lowest acute effect value is > 1 mg/L.

Chronic data are available only for algae (based on geometric mean of propionic acid, isobutyric acid and 2 -ethylhexanoic acid: EC10 > 1 mg/L), therefore classification is based on the available chronic (algae) and acute toxicity (fish, Daphnia and algae) data. The data available for chronic classification are (not adequately) conclusive but not sufficient for classification. The chronic data indicate that 4 -chlorobutyryl chloride is not to be classified as hazardous to the aquatic environment.The lowest acute effect value is between 10 -100 mg/L (based on geometric mean of propionic acid, isobutyric acid and 2 -ethylhexanoic acid, Scenedesmus subspicatus, 72-h ErC50 = 50.6 mg/L). But 4 -chlorobutyryl chloride / 4 -chlorobutyric acid is readily biodegradable and the log Pow is < 4.Therefore, the substance is not be classified as chronically hazardous to the environment.

Atmospheric compartment

The test substance is not listed in Annex 1 of Regulation (EC) 2037/2000 on substances that deplete the ozone layer.

The test substance does not belong to the greenhouse gases listed in P Forster, PV Pamaswamy et al. Changes in Atmospheric Constituents and Radiative Forcing. In: Climate Change 2007: The Physical Basis. Contribution of Working Goup 1 to the Fourth Assessment Report of the Intergovernmental Panel on climate Change.