Registration Dossier
Registration Dossier
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EC number: 206-341-3 | CAS number: 329-01-1
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Title:
- No information
- Author:
- GUROVA AI, ALEKSEEVA NP, GORLOVA OE, CHERNYSHOVA RA (1976)|Gig Tr Prof Zabol, 3, 53-55 (Russian)
Materials and methods
- Principles of method if other than guideline:
- The test substance was applied by repeated introduction in stomach for 22, 45, or 90 days. Animals were observed for mortality and clinical signs.
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α,α-trifluoro-3-tolyl isocyanate
- EC Number:
- 206-341-3
- EC Name:
- α,α,α-trifluoro-3-tolyl isocyanate
- Cas Number:
- 329-01-1
- Molecular formula:
- C8H4F3NO
- IUPAC Name:
- 1-isocyanato-3-(trifluoromethyl)benzene
- Reference substance name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- IUPAC Name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- Details on test material:
- Test substance: no data
Constituent 1
Constituent 2
Test animals
- Species:
- other: rodent
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 22, or 45, or 90 days
- Frequency of treatment:
- no details reported
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 200, 100, and 50 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
repeated introduction in stomach in doses of 1/5, 1/10, and 1/20 LD50 (total cumulative dose= 4.5 times LD50; LD50= 975
mg/kg in rat and mouse) did not provoke the death of animals; increasing excitement, body weight loss,
respiratory effects
Applicant's summary and conclusion
- Executive summary:
The test substance was applied by repeated introduction in stomach for 22, 45, or 90 days. Animals were observed for mortality and clinical signs.
Doses of 1/5, 1/10, and 1/20 LD50 (total cumulative dose= 4.5 times LD50; LD50= 975 mg/kg bw in rats and mouse). These doses did not provoke the death of animals; an increasing excitement, body weight loss, and respiratory effects were found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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