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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only abstract available; original reference in Russian

Data source

Reference
Reference Type:
publication
Title:
Data to substantiate of the maximum permissible level of m-trifluoromethylphenyl isocyanate and butyl isocyanate in the air of work areas
Author:
Gurova AI, Alekseeva NP, Gorlova OE, Chernyshova RA
Year:
1976
Bibliographic source:
Gig. Tr. Pro. Zabol 3, 53-55, cited from English abstract.

Materials and methods

Principles of method if other than guideline:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α,α-trifluoro-3-tolyl isocyanate
EC Number:
206-341-3
EC Name:
α,α,α-trifluoro-3-tolyl isocyanate
Cas Number:
329-01-1
Molecular formula:
C8H4F3NO
IUPAC Name:
1-isocyanato-3-(trifluoromethyl)benzene
Constituent 2
Reference substance name:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
IUPAC Name:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
Details on test material:
Test substance: m-trifluormethylphenyl isocyanate, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 months
Frequency of treatment:
periodic (no furher data)
Doses / concentrations
Remarks:
Doses / Concentrations:
1.3, 6.1 and 11.2 mg/m³
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: 3 months

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Histopathological findings: neoplastic:
not specified

Effect levels

Dose descriptor:
LOAEL
Effect level:
11.2 mg/m³ air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: functional and histological changes 
Remarks on result:
other: functional and histological  changes in lungs, liver, kidneys, heart, and brain

Target system / organ toxicity

Critical effects observed:
yes
Lowest effective dose / conc.:
11.2 mg/m³ air
System:
other: lungs, liver, kidneys, heart, and brain
Organ:
other: functional and histological  changes in lungs, liver, kidneys, heart, and brain
Treatment related:
yes
Dose response relationship:
yes

Any other information on results incl. tables

At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain; at 1.3 mg/m³ the test substance is nontoxic for rats. All symptoms of poisoning disappeared within 3 months after the experiments are ceased.

Applicant's summary and conclusion

Executive summary:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³.

At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain;

at 1.3 mg/m³ the test substance is nontoxic for rats and mice. All symptoms of poisoning disappear within 3 months after the experiments are ceased.