Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 206-341-3 | CAS number: 329-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Guidance on Safe Use
Administrative data
First-aid measures
Inhalation:
Get medical attention immediately. Move affected person to fresh air. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. Keep person warm and at rest. Maintain an open airway. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. In the event of any complaints or symptoms, avoid further exposure. Medical surveillance for at least 48 hours.
INFORMATION FOR THE PHYSICIAN: Treat with a corticoid metered aerosol depending on the amount inhaled. If appropriate symptoms occur or inhalation of large quantities is suspected, administer cortisone intravenously in addition.
Ingestion:
Get medical attention immediately. Make the patient drink a large quantity of water, if possible with an addition of activated carbon, immediately, and then at frequent intervals. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Keep person warm and at rest. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.
Skin contact:
Get medical attention immediately. Remove contaminated clothing and shoes. Wash the skin immediately with plenty of soap and water; cleaning immediately with polyethyleneglycol 400 and washing subsequently with plenty of soap and water would be more effective. Wash skin immediately with plenty of soap and water even when contact with the product is suspected. Wash clothing before reuse. Clean shoes thoroughly before reuse.
Eye contact:
Get medical attention immediately. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician.
Indication of any immediate medical attention and special treatment needed:
Notes to physician:
Basic aid, decontamination, symptomatic treatment. Treat with a corticoid metered aerosol depending on the amount inhaled. If appropriate symptoms occur or inhalation of large quantities is suspected, administer cortisone intravenously in addition Medical surveillance for at least 48 hours.
Fire-fighting measures
Extinguishing media - Suitable extinguishing media:
In case of fire, use water spray (fog), foam, dry chemical or CO2.
Extinguishing media - Unsuitable extinguishing media:
Do not use water jet.
Special hazards arising from the substance or mixture - Hazards from the substance or mixture:
Combustible liquid. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion.
Special hazards arising from the substance or mixture - Hazardous combustion products:
Decomposition products may include the following materials: carbon oxides, nitrogen oxides, halogenated compounds, hydrogen cyanide, Hydrogen fluoride
Advice for firefighters - Special precautions for firefighters:
Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fireexposed containers cool. This material is toxic to aquatic organisms. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain.
Advice for firefighters - Special protective equipment for fire-fighters:
Fire-fighters should wear appropriate protective equipment and selfcontained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.
Accidental release measures
Personal precautions, protective equipment and emergency procedures:
No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Avoid breathing vapour or mist. Provide adequate ventilation. Put on appropriate personal protective equipment (see: Exposure controls/personal protection).
Environmental precautions:
Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Methods and materials for containment and cleaning up - Small spill:
Stop leak if without risk. Use spark-proof tools and explosion-proof equipment. Take up with a moist, liquid-binding material (e.g. sand, sawdust or chemical binder based on hydrated calcium silicate) and treat carefully with diluted ammonia solution. Do not firmly seal waste containers (risk of CO2 generation!). Once the reaction is fully complete, pass on to disposal facilities. Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilt product.
Methods and materials for containment and cleaning up - Large spill:
Stop leak if without risk. Prevent entry into sewers, water courses, basements or confined areas. Use spark-proof tools and explosionproof equipment. Collect spillage. Absorb with an inert material and place in an appropriate waste disposal container. Do not firmly seal waste containers (risk of CO2 generation!). Dispose of via a licensed waste disposal contractor. Carefully decompose residues with an aqueous ammonia solution. Note: see section 1 for emergency contact information and section 13 for waste disposal. Contaminated absorbent material may pose the same hazard as the spilt product.
Handling and storage
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.
Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate.
Precautions for safe handling:
Put on appropriate personal protective equipment (ee: Exposure controls/personal protection). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Persons with a history of skin sensitisation problems or asthma, allergies or chronic or recurrent respiratory disease should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not breathe vapour or mist. Do not ingest. Avoid release to the environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source.
Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use non-sparking tools. Take precautionary measures against electrostatic discharges. To avoid fire or explosion, dissipate static electricity during transfer by earthing and bonding containers and equipment before transferring material. Empty containers retain product residue and can be hazardous.
Conditions for safe storage, including any incompatibilities:
Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see: Stability and reactivity) and food and drink. Eliminate all ignition sources. Separate from oxidizing materials.
Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination.
Specific end use(s) Recommendations: Not available
Industrial sector specific solutions: Not available
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- UN3382
Shipping information
- Proper shipping name and description:
- TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S.
m-Trifluoromethylphenylisocyanate - Chemical name:
- m-Trifluoromethylphenylisocyanate
- Language:
- English
- Labels:
- Toxic
Fish and tree
Special provisions / remarks
- Special provisions:
- Hazard identification number 66
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- UN3382
Shipping information
- Proper shipping name and description:
- TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S.
m-Trifluoromethylphenylisocyanate - Chemical name:
- m-Trifluoromethyl-phenylisocyanate
- Language:
- English
- Labels:
- Toxic
Fish and tree
Special provisions / remarks
- Remarks:
- Hazard identifiaction number 66
Marine transport (UN RTDG/IMDG)
- UN number:
- UN3382
Shipping information
- Proper shipping name and description:
- TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S.
m-Trifluoromethylphenylisocyanate - Chemical name:
- m-Trifluoromethyl-phenylisocyanate
- Labels:
- Toxic
Fish and tree
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- -
Shipping information
- Proper shipping name and description:
- -
- Chemical name:
- -
- Labels:
- -
Special provisions / remarks
- Remarks:
- Forbidden
Additional transport information
Additional information
- Special provisions / remarks / other:
- Highly toxic.
Irritating to skin and eyes.
Environmetally hazardous substance.
Keep dry.
Keep away from cargo susceptible to odour.
Keep away from foodstuffs, acids and alkalis.
Exposure controls / personal protection
Ingredient name: 3-trifluoromethyl-phenyl isocyanate
Occupational exposure limits: ARW (Europe). Lanxess−internal value for the maximum workplace concentration (WEL) TWA: 0,02 mg/m³, (NCO) 8 hour(s). STEL: 0,02 mg/m³, (NCO), 1 times per shift, 15 minute(s).
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.
Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate.
Control parameters - Recommended monitoring procedures:
If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to European Standard EN 689 for methods for the assessment of exposure by inhalation to chemical agents and national guidance documents for methods for the determination of hazardous substances.
Risk management measures Occupational exposure controls - Technical measures:
Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. The engineering controls also need to keep gas, vapour or dust concentrations below any lower explosive limits. Use explosion-proof ventilation equipment.
Exposure controls - Risk management measures Occupational exposure controls - Personal protection measures:
Respiratory protection:
Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Recommended: Full mask with type ABEK filter if product forms vapours . If larger quantities escape, self-contained breathing apparatus must be used.
Hand protection:
Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. After contamination with product change the gloves immediately and dispose of them according to relevant national and local regulations Recommended: (< 1 hour) Polychloroprene - CR, Fluorinated rubber - FKM or Polyvinyl chloride - PVC
Eye protection:
Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. Recommended: Tightly fitting safety goggles.
Skin protection:
Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Recommended: chemical-resistant protective suit
Hygiene measures:
Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.
Exposure controls - Environmental exposure controls - Technical measures:
Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.
Stability and reactivity
Reactivity: No specific test data related to reactivity available for this product or its ingredients.
Chemical stability: Hazardous polymerization may occur under certain conditions of storage or use.
Possibility of hazardous reactions: Hazardous reactions or instability may occur under certain conditions of storage or use.
Conditions to avoid: Reactive with water , alcohols , acids , alkalis and amines. With water (in a closed container), pressure will increase and create a risk of bursting. Do not pressurise, cut, weld, braze, solder, drill, grind or expose containers to heat or sources of ignition.
Incompatible materials: Not applicable.
Hazardous decomposition products: Under normal conditions of storage and use, hazardous decomposition products should not be produced.
Disposal considerations
Waste treatment methods - Product - Methods of disposal:
Examine possibilities for re-utilisation. Product residues and uncleaned empty containers should be packaged, sealed, labelled, and disposed of or recycled according to relevant national and local regulations. Where large quantities are concerned, consult the supplier. When uncleaned empty containers are passed on, the recipient must be warned of any possible hazard that may be caused by residues. For disposal within the EC, the appropriate code according to the European Waste List (EWL) should be used. It is among the tasks of the polluter to assign the waste to waste codes specific to industrial sectors and processes according to the European Waste List (EWL).
Waste treatment methods - Product - Hazardous waste:
The classification of the product may meet the criteria for a hazardous waste.
Packaging - Methods of disposal:
The generation of waste should be avoided or minimised wherever possible. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible.
Packaging - Special precautions:
This material and its container must be disposed of in a safe way. Care should be taken when handling emptied containers that have not been cleaned or rinsed out. Empty containers or liners may retain some product residues. Vapor from product residues may create a highly flammable or explosive atmosphere inside the container. Do not cut, weld or grind used containers unless they have been cleaned thoroughly internally. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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