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EC number: 206-341-3
CAS number: 329-01-1
A test substance is predicted to be an ocular irritant if the mean
relative tissue viability (%) exposed to the test substance is<50%.
As can be seen from the information in the Table below the test substance
m-Trifluoromethylphenylisocyanate was detected as irritant to the cornea
epithelium in this test model.
Compound Cell viability [%] Evaluation
m-Trifluoromethylphenylisocyanate 29.21 irritant
Positive control 20.04
Negative control 100.00
This in vitro study for assessing ocular irritation of compounds using a
human epithelial corneal cell model was performed in 2011. The model
used is standardized and commercially available (SkinEthicTM Human
Corneal Epithelial Model (HCE); SkinEthic, France).
Undiluted m-trifluoromethylphenylisocyanate was applied topically to the
HCE tissue, i.e. 30 mg per insert. (plus 30 µl PBS to moisten and ensure
good contact with the skin; three replicates)
After an exposure period of 60 minutes, followed by a 16 hours
post-treatment incubation period, the cell viability was 2% (rounded) as
measured by a MTT conversion assay.
The results of the concurrent negative (NC, PBS) and positive control
(PC, 1H-1,2,4-Triazole-3-thiol) demonstrated the viability (NC) and
sensitivity (PC) of the test model.
The results show that m-trifluoromethylphenylisocyanate is predicted as
ocular irritant under the conditions of this test method.
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