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EC number: 200-274-3
CAS number: 56-45-1
No experimental test results for the substance are available.
Results form other proteinogenic amino acids (L-valine, D/L-methionine,
L-arginine) clearly indicate that these substances show no/very low
toxicty to fish even if applied in very high concentrations (>1 g/l).
The LC50 for fish (Pimephales promelas) to L-serine was estimatied to be
120 g/l by trend analyis using the OECD QSAR Toolbox (Version 3.0; data
base version: 3.4.2/3.1.2). Although the substance was not in the
applicability domain of the prediction due to the very low logKow of the
substance the results clearly indicate a very low toxicity / absence of
toxicity to fish.
This very low fish toxicity was further confirmed by the result of a
QSAR (EcoSAR, EpiSuite) that predicted an 96h-LC50 of 354 g/L for
L-serine (class Aliphatic Amines-acid).
Very low aquatic toxicty was already shown for algae and daphnia. A
weight of evidence approach with data from Read-across substances (other
proteinogenic amino acids) and QSARs convincingly prove absence of
toxicity /low toxicity to fish. Available data are sufficient for
classification and risk characterisation. Therefore it is justified not
to perform further testing on vertebrates (fish) with L-serine for
animal wellfare reasons.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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