Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 200-274-3 | CAS number: 56-45-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
According to an OECD301F study (see 2012 -0032 -DGO) L-serine did not show significant toxic effects to the popoulation of microrganisms in waste water (activated sludge) at a nominal concentration of 104 mg/l. L-Serine is readily biodegradable. Further, in an older publication it was reportet that 29 % of L-serine (initial concentration of 500 mg/l) was degraded by activated sludge after 24 hours incubation (see chapter 5.2.1). This clearly indicate that L-serine is not toxic to activated sludge. This is supported by an old study which also indicate low/no toxicity (81 -0280 -DKO).
In accordance with REACH Annex VIII, No. 9.1.4 column 2, the toxicity test to microorganisms does not need to be conducted as there are mitigating factors indicating that the microbial toxicity is unliekly to occur as well as because the substance is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
