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EC number: 915-748-1
CAS number: -
The registration substance is a reaction mixture comprising
approximately 60% w/w of 4,4,13,13
constituent) and 40% w/w of 3,15
No data are available for short- or long-term toxicity of the
registration substance to aquatic organisms. These endpoints are
therefore addressed by weight of evidence from data for two related
constituent, CAS 56706-10-6) and polysulfides,
bis[3-(triethoxysilyl)propyl] (containing S2, S3 and S4 constituents,
Reliable short-term toxicity tests results are available for
freshwater fish (Danio rerio), invertebrates (Daphnia magna)
and algae (Desmodesmus subspicatus) for
(CAS 56706-10-6). The relevant short-term values are:
Fish: LC50 (96 h): >1000 mg/l
Daphnia: EC50 (48 h): <1 mg/l
Daphnia: EC50 (48 h): 4 mg/l;
Algae: EC50 (72 h): >500 mg/l; NOELR: 32 mg/l
It is likely that the Daphnia magna and algae were subject to
physical effects of undissolved test substance (or precipitated
cross-linked oligomers of the silanol) and the results of these tests
therefore need to be treated with caution. The substance itself appears
to be non-toxic at the solubility limit; this interpretation is
supported by QSAR, which predicts that no short-term or long-term
ecotoxic effects would be expressed in fish, invertebrates or algae in
either short- or long-term tests at the limit of solubility of the
Reliable short-term toxicity tests results are available for freshwater
fish (Danio rerio), invertebrates (Daphnia magna) and
algae (Desmodesmus subspicatus) for polysulfides,
bis[3-(triethoxysilyl)propyl] (CAS 211519-85-6). The relevant short-term
Fish: LC50 (96 h): >10000 mg/l; NOELR: ≥10000 mg/l
Daphnia: EC50 (48 h): >10 mg/l; NOELR: ≥10 mg/l
Algae: EC50 (72 h): 700 mg/l; EC10: 60 mg/l
It is likely that, because of the prolonged test medium preparation
phases, the test organisms were predominantly exposed to a mixture of
undissolved parent substance, silanol hydrolysis product and
precipitated oligomeric or cross-linked condensation products. Physical
effects are likely to have had a role in the studies that showed effects.
The data have been obtained with test media that are likely to have
contained the test substance at its solubility limit and the hydrolysis
products of the substances. Nominal concentrations (saturated test
media) were applied as well as WAFs prepared. The lowest LL50/EL50
values that are adjudged not to have been influenced by the
presence of undissolved material in the test media have been chosen to
describe the hazard properties of the registration substance.
The hydrolysis products are
freely soluble at low concentrations. It is therefore appropriate to
base PNECs for the hydrolysis products on the loading rates used in the
preparation of the test media. The parent substance itself appears to be
non-toxic at the solubility limit.
Based on this approach the following data are considered appropriate for
assessing the registration substance.
Fish 96-hour LL50: >1000 mg/l (nominal) (read across from CAS
Invertebrate 48-hour EL50: >10 mg/l (nominal) (read across
from CAS 211519-85-6)
Algae 96-hour EC50: 700 mg/l and NOEC: 60 mg/l (nominal)
(read across from CAS 211519-85-6)
Data waivers are applicable to long-term fish and invertebrate toxicity
endpoints based on the absence of short-term aquatic toxicity at the
limit of solubility, and the difficulty in preparing the test media in
Refer to Section 7.0 for further discussion of the approach to
chemical safety assessment and justification for read across.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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