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EC number: 915-748-1
CAS number: -
No sensitisation data are available for the registered substance,
therefore this endpoint is addressed by read-across from a related
substance. The key skin sensitisation study is a reliable adjuvant study
conducted according to OECD 406 on a closely related material. The study
identified a sensitisation index of 5% (EU criteria for sensitisation by
skin contact would require a positive response in at least 30% of the
Table 1: Incidence
of dermal response to challenge dosing
SENSITIZATION INCIDENCE INDEX**
HCA in vehicle
0 no reaction or
very slight dispersed redness. No swelling.
1 slight patchy or
2 moderate and
confluent erythema and/or slight swelling
3 severe erythema
and/or moderate to severe swelling
incidence index: number of animals with dermal scores greater than
those of the negative control group at 24h or 48h, divided by the
number of animals tested. Grades of 1 or greater are considered
indicative of sensitization in the positive control group
index: the sum of test grades divided by the number of animals
tested (given for 24h and 48h observations separately)
The registered substance is a reaction
mixture comprising approximately 60% w/w of 4,4,13,13
constituent) and 40% w/w of 3,15-Dioxa-8,9,10-trithia-4,14-disilaheptadecane,4,4,14,14-tetraethoxy-
Skin sensitisation data for this substance
were obtained by read-across from a closely related substance
polysulfides, bis[3-(triethoxysilyl)propyl] (CAS 211519-85-6), which is
a reaction mass containing principally the S2 (15-60%), S3 (25-40%) and
S4 (5-30%) constituents. For this purpose only the key study has been
incorporated. The key study was a guideline study (reliability 1).
It is considered
appropriate to use these surrogate data since the mixed product gave a
clear negative result and there is no reason to expect a positive result
from different proportions of constituents.
read-across data do not support classification for skin sensitization
according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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