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EC number: 236-144-8 | CAS number: 13189-00-9
Zinc compounds (zinc sulphate):
Methacrylic acid/methyl methacrylate:
EU RAR (2002) Methyl methacrylate. Risk assessment report, 1st priority list, Volume 22, European Commission, Institute for Health and Consumer Protection, European Chemicals Bureau.
EU RAR (2004) Zinc sulphate. Risk assessment report, 2nd priority list, Volume 46, European Commission, Institute for Health and Consumer Protection, European Chemicals Bureau.
The basic assumption to deduce the toxicological properties of the registered substance (based on its behaviour in water) is that after intake of the substance, it is mainly transformed into the ionic species and zinc compounds and the methacrylic part of the substance are the determining factors of the biological activities of the registered substance.
This assumption is confirmed by the genotoxicity studies performed on the registered substance where negative reponse was found in Ames test and in an in vitro gene mutation in mammalian cells test. These results are in line with the numerous studies performed on both zinc compounds and methacrylate compounds. Therefore the genotoxic potential of the registered substance was deduced from all the data available on these compounds. The overall weight of evidence from the existing in vitro and in vivo genotoxicity assays suggest that zinc compounds and methacrylate compounds do not have biologically relevant genotoxic activity, which was confirmed by other regulatory reviews of the genotoxicity of zinc compounds and methacrylate compounds.
Thus the registered substance does not need to be classified for genotoxicity under the Directive 67/548/EEC and the CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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