Registration Dossier
Registration Dossier
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EC number: 272-574-2 | CAS number: 68890-66-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Octopirox was tested for a possible skin sensitizing potential in guinea pigs using the method of Buehler, the maximization test according to Magnusson and Kligman, and the repated insult patch test in human volunteers. No indications of hypersensitive reactions were observed in any of the studies. Based on all available study results, Octopirox is considered to have no skin sensitizing potential. In addition, Octopirox was also tested for possible photocontact sensitivity and/or phototoxicity in guinea pigs and in human volunteers. No indications of phototoxic properties and/or photocontact sensitivity were observed. Based hereupon, Octopirox is not considered to cause photosensitization.
Migrated from Short description of key information:
Octopirox does not induce any signs of sensitization in animals as well as in human volunteers and does not cause photosensitization.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Octopirox is not a skin sensitizer and does not cause photosensitization neither in animals nor in humans. Based hereupon no indications exist that Octopirox may possess respiratory sensitization properties.
Migrated from Short description of key information:
Octopirox is not a skin sensitizer and does also not cause photosensitization neither in animals nor in human volunteers. Based on all available data a respiratory sensitization potential is also not deducible.
Justification for classification or non-classification
Octopirox is not a skin sensitizer and does also not cause photosensitization neither in animals nor in human volunteers. Based hereupon a classification is not deducible.
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