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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 07 October 2009 and 19 January 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Date of inspection: 2009-09-15 Date of Signature: 2009-11-26
Type of method:
flask method
Remarks:
The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Key result
Water solubility:
265 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 5.9 - <= 6
Details on results:
Please see section 'remarks on results including tables and figures'.

Results

Preliminary test

The preliminary estimate of water solubility was 269 g/l.

Definitive test

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Table 2.

Solution

Mean peak area

Standard 39.1 mg/l

5.030

Standard 39.7 mg/l

5.125

Sample 1A

3.591

Sample 1B

3.619

Sample 2A

3.563

Sample 2B

3.548

Standard 39.1 mg/l

5.056

Standard 39.7mg/l

5.126

Sample 3A

3.574

Sample 3B

3.538

Sample 4A

3.511

Sample 4B

3.574

Sample 5A

3.604

Sample 5B

3.604

The concentration (g/l) of test material in the sample solutions is shown in the following table:

Table 3.

Sample Number

Time shaken at

~ 30ºC (hours)

Time equilibrated at 20ºC (hours)

Concentration (g/l)

Solution pH

1

72

24 [10ºC]

269

5.9

2

72

24 [30ºC]

265

5.9

3

72

24

264

5.9

4

48

24

263

5.9

5

24

24

268

6.0

Mean result (at 20.0±0.5°C): 265 g/l.

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 65 mg/l. This was satisfactory with a correlation coefficient of 1.000 being obtained.

              

Conclusions:
Interpretation of results: very soluble (> 10000 mg/L)
The water solubility of the test material has been determined to be 265 g/l of solution at 20.0 ± 0.5°C.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the solubility of the test material (range 265 to 269 g/l). This study is considerd to be acceptable and satisfies the guideline requirement for this endpoint. This study was performed in accordance with an accepted method (EU Method A.6) and under the conditions of GLP and is considered to be appropriate and reliable for use as a key study in accordance with Regulation (EC) No. 1907/2006 (REACH). No further testing is required.

Executive summary:

Method

The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.

Conclusion

The water solubility of the test material has been determined to be 265 g/l of solution at 20.0±0.5°C.

The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the solubility of the test material (range 265 to 269 g/l).

Description of key information

The water solubility of trisodium trimetaphosphate was determined according to EU Method A.6 (Water solubility) and under the conditions of GLP. 

Key value for chemical safety assessment

Water solubility:
265 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material has been determined to be 265 g/l of solution at 20.0 ± 0.5°C. The pH of this solution was in the range: 5.9 6.0.

The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the solubility of the test material (range 265 to 269 g/l).