Registration Dossier
Registration Dossier
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EC number: 232-088-3 | CAS number: 7785-84-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No detail on methodology and results. All studies included in the report are brief summaries.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details on methodology included within study report.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Trisodium trimetaphosphate
- EC Number:
- 232-088-3
- EC Name:
- Trisodium trimetaphosphate
- Cas Number:
- 7785-84-4
- Molecular formula:
- H3O9P3.3Na or O3P3.3Na
- IUPAC Name:
- Sodium trimetaphosphate
- Test material form:
- not specified
- Details on test material:
- - Name of test material : sodium trimetaphosphate
- Analytical purity: No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- 4640 mg/kg
- No. of animals per sex per dose:
- 2 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 640 mg/kg bw
- Mortality:
- No unscheduled deaths were recorded during the study
- Clinical signs:
- other: No signs of toxicity or local effects were noted during the course of the study.
- Gross pathology:
- No data (not examined)
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for sodium trimetaphosphate in rabbits was determined to be > 4640 mg/kg. Due to the lack of methodological details and the lack of details regarding the purity of the test material this study is not considered to be acceptable for the purpose of classification and labelling in accordance with Regulation (EC) no. 1272/2008 (EU CLP). This study supports the conclusion that trisodium trimetaphosphate is not considered to be acutely toxic via the dermal route.
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