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EC number: 915-589-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Additional toxicological data

Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil: simulation testing
- Type of information:
- (Q)SAR
- Remarks:
- Diisopropyl biphenyl isomer mixture (DIPB; CAS-No.: 69009-90-1) represents one main constituent of the registered UVCB (Alkylation and transalkylation products of biphenyl with propene)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- The substance is not compliant with the applicability domain of the model. However, this calculation is used as supporting information and is considered acceptable for this purpose. It is adequately documented and justified. For more detail see field `overall remarks, attachments´.
- Justification for type of information:
- 1. SOFTWARE
Vega version 1.1.4
2. MODEL (incl. version number)
Persistence in soil Model version 1.0.0
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached information on the model provided by the developer. Further information on the OECD criteria as outlined by the applicant is provided below under "Any other information of materials and methods incl. tables"
5. APPLICABILITY DOMAIN
See attached information and information as provided in "Any other information on results incl. tables".
6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section. - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: Vega v1.1.4
- Model(s) used: Persistence in soil Model version 1.0.0
Full reference and details of the used formulas can be found in:
A. Manganaro, F. Pizzo, A. Lombardo, A. Pogliaghi, E. Benfenati, “Predicting persistence in the sediment compartment with a new automatic software based on the k-Nearest Neighbor (k-NN) algorithm”, Chemosphere (2015), accepted paper.
Gouin, T., Cousins, I., Mackay, D., “Comparison of two methods for obtaining degradation halflives”, Chemosphere 56, 2004, 531-535
Gramatica, P., Papa, E., “Screening and ranking of POPs for Global Half-Life: QSAR approaches for prioritization based on molecular structure”, Environ. Sci. Technol. 41, 2007, 2833-9.
- Model description: see field 'Justification for non-standard information', 'Attached justification' and 'any other information on Material and methods'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'overall remarks' - GLP compliance:
- no
- Radiolabelling:
- no
- Oxygen conditions:
- aerobic
- Remarks on result:
- other: DIPB was predicted to be not persistent (nP) in soil.
- Transformation products:
- not specified
- Endpoint:
- biodegradation in soil: simulation testing
- Type of information:
- (Q)SAR
- Remarks:
- Triisopropyl biphenyl isomer mixture (TIPB; CAS-No.: 29225-91-0) represents one main constituent of the registered UVCB (Alkylation and transalkylation products of biphenyl with propene)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- The substance could be out of the applicability domain of the model. However, this calculation is used as supporting information and is considered acceptable for this purpose. It is adequately documented and justified. For more detail see field `overall remarks, attachments´.
- Justification for type of information:
- 1. SOFTWARE
Vega version 1.1.4
2. MODEL (incl. version number)
Persistence in soil Model version 1.0.0
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached information on the model provided by the developer. Further information on the OECD criteria as outlined by the applicant is provided below under "Any other information of materials and methods incl. tables"
5. APPLICABILITY DOMAIN
See attached information and information as provided in "Any other information on results incl. tables".
6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section. - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: Vega v1.1.4
- Model(s) used: Persistence in soil Model version 1.0.0
Full reference and details of the used formulas can be found in:
A. Manganaro, F. Pizzo, A. Lombardo, A. Pogliaghi, E. Benfenati, “Predicting persistence in the sediment compartment with a new automatic software based on the k-Nearest Neighbor (k-NN) algorithm”, Chemosphere (2015), accepted paper.
Gouin, T., Cousins, I., Mackay, D., “Comparison of two methods for obtaining degradation halflives”, Chemosphere 56, 2004, 531-535
Gramatica, P., Papa, E., “Screening and ranking of POPs for Global Half-Life: QSAR approaches for prioritization based on molecular structure”, Environ. Sci. Technol. 41, 2007, 2833-9.
- Model description: see field 'Justification for non-standard information', 'Attached justification' and 'any other information on Material and methods'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'overall remarks' - GLP compliance:
- no
- Radiolabelling:
- no
- Oxygen conditions:
- aerobic
- Remarks on result:
- other: TIPB was predicted to be vP in soil.
- Transformation products:
- not specified
- Endpoint:
- biodegradation in soil: simulation testing
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Transformation products:
- no
Referenceopen allclose all
For detailed information on the results please refer to the attached report.
For detailed information on the results please refer to the attached report.
Description of key information
Alkylation and transalkylation products of biphenyl with propene is an UVCB substance composed of different constituents. Each constituent is present as a mixture of isomers with unknown constituents. Based on the complex composition in combination with the physico-chemical properties of the substance biodegradation simulation testing is technically not feasible. This was assessed within a feasibility study conducted according to OECD 309 guideline. In a weight of evidence approach, considering study results and QSAR estimates for the main constituents of the UVCB, it was concluded that alkylation and transalkylation products of biphenyl with propene is potentially persistent or very persistent.
Key value for chemical safety assessment
Additional information
Based on the complex composition in combination with the physico-chemical properties of the substance biodegradation simulation testing is considered as technically not feasible. This was assessed within a feasibility study conducted according to OECD 309 guideline. Persistence in soil was estimated by QSAR calculations for the two main constituents DIPB and TIPB. These QSAR results were used in a weight of evidence approach for the persistence assessment of the UVCB substance.
The persistence of the main constituents DIPB and TIPB in soil was estimated using the QSAR model VEGA 1.1.4 “Persistence (soil) model” (IRFMN) 1.0.0. For DIPB the model predicts no persistence (nP) whereas the prediction for TIPB is very persistent (vP). The QSAR estimate for DIPB should be considered with caution, since the substance does not fall within the applicability domain of the model. For both isomers, DIPB and TIPB, the performance of the model on similar molecules is good, even though isopropyl chains are missing in the list of the most similar substances in the training set. The use of the prediction as supporting information within a weight of evidence approach for the persistency assessment of the UVCB substance is considered acceptable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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