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EC number: 915-589-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 20, 1986 - Feb 25, 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA (US EPA)
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA (US EPA)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diisopropylbiphenyl and triisopropylbiphenyl
- EC Number:
- 915-589-8
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Diisopropylbiphenyl and triisopropylbiphenyl
- Details on test material:
- - Name of test material (as cited in study report): Diisopropyl biphenyl, isomeric mixture (acronym used: DIPB or di-IPB/tri-IPB)
- Substance type: organic
- Density: 0.9669 g/ml
- Physical state: clear liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Isomers composition: no data
- Lot/batch No.: NBP-3184823
- Expiration date of the lot/batch: no data
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species: New Zealand White, albino rabbits
- Source: Hazleton-Dutchland, Inc.; Denver, Pennsylvania
- Age at study initiation: young adult
- Weight at study initiation: no data
- Housing: individually in suspended stainless steel cages
- Diet: Lab Rabbit Chow HF, ad libitum:
- Water: ad libitum
- Acclimation period: 22 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 16°C - 21°C (60 - 70°F)
- Humidity (%): 30-70%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- other: see below
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml (undiluted) per site - Duration of treatment / exposure:
- Single 4- or 24-hour exposure
- Observation period:
- 3-14 d
- Number of animals:
- 6 (2 males, 4 females)
- Details on study design:
- TEST SITE
The test material was applied to four intact sites on each animal.
Two sites were semi-occluded, two sites were occluded for 24 h.
Exposure period: Two sites for 4 h, two sites for 24 h
ADMINISTRATION OF TEST MATERIAL
- 4-h exposure, semi-occlusive
- 24-h exposure, occlusive
SCORING SYSTEM:
All sites were evaluated for erythrema, edema and other evidence of dermal irritation according to the DRAIZE scoring system.
Adjacent areas of untreated skin were used for comparison.
Special notations were made to describe evidence of epidemal and subepidermal destruction.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- (24 h exposure)
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 4.3
- Max. score:
- 8
- Reversibility:
- fully reversible
- Remarks:
- 10 d
- Irritation parameter:
- erythema score
- Basis:
- animal: 8876
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- erythema score
- Basis:
- animal: 8882
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- erythema score
- Basis:
- animal: 8897
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- erythema score
- Basis:
- animal: 8904
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- erythema score
- Basis:
- animal: 8906
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- erythema score
- Basis:
- animal: 8907
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- edema score
- Basis:
- animal: 8876
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- edema score
- Basis:
- animal: 8882
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- edema score
- Basis:
- animal: 8897
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- edema score
- Basis:
- animal: 8904
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- edema score
- Basis:
- animal: 8906
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- edema score
- Basis:
- animal: 8907
- Time point:
- 24/48/72 h
- Score:
- 2.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- other: desquamation
- Basis:
- animal: 8882
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritation parameter:
- other: desquamation
- Basis:
- animal: 8897
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 10 day
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritation parameter:
- other: desquamation
- Basis:
- animal: 8904
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, mean value over two treated sites (left and right forelimb)
- Irritation parameter:
- other: desquamation
- Basis:
- animal: 8906
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritation parameter:
- other: desquamation
- Basis:
- animal: 8907
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritation parameter:
- other: desquamation
- Basis:
- animal: 8876
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritation parameter:
- other: superficial necrosis
- Basis:
- animal: 8897
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritation parameter:
- other: superficial necrosis
- Basis:
- animal: 8906
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: 4 hour exposure, two treated sites (left and right forelimb)
- Irritant / corrosive response data:
- Irritation was generally mild to moderate (for both 4-h exposure under semi-occlusive and 24-h exposure under occlusive covering). In isolated cases after 4h exposure, scores were graded with 3 to 4 from 24 to 48 h. 1/6 animal exhibited an erythema scored with 4 until day 7, but completely cleared by day 10.
Although 3 of 6 animals had superficial (epidermal) tissue damage at one or more sites, no subepidermal tissue damage was seen.
Desquamation and/or superficial necrosis were not reversible in 5 of 6 animals within 10 or 14 days. - Other effects:
- see above
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria met, classified as Skin Irrit. 2 according to Regulation (EC) No 1272/2008
- Conclusions:
- A reliable study, conducted in accordance with FIFRA and TSCA guidelines, found the test material to be irritating to the skin of rabbits. Although the cut-off criteria of ≥ 2.3 for edema and erythema was only reached for one rabbit, desquamation and/or superficial necrosis were noted in all 6 animals and desquamation was not reversible within the observation period (10 to 14 days) in 5 animals.
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