Registration Dossier
Registration Dossier
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EC number: 915-589-8 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No detailed measurements on ADME are available for alkylation and transalkylation products of biphenyl with propene. Acute and repeated-dose studies with the registration substance suggests substantial intestinal, but low dermal uptake, and intense hepatic metabolism, once the substance has been absorbed.
Key value for chemical safety assessment
Additional information
Basic toxicokinetics
For alkylation and transalkylation products of biphenyl with propene, no data about ADME have been located. The acute oral toxicity study (Biodynamics 1986) and in particular the oral 28 -day study (Harlan 2014) with alkylation and transalkylation products of biphenyl with propene, provides evidence of ready systemic availability via the oral route.
Dermal absorption
No data is available. Dermal uptake is assumed to be limited as compared with oral ingestion, based on the marked differences in either profiles of acute intoxication.
For biphenyl [CAS no. 92 -52 -4], the parent compound of alkylation and transalkylation products of biphenyl with propene, dermal absorption was determined in an in-vitro skin absorption study according to OECD TG 428 (Skin Absorption: In Vitro Method). In this study with human skin samples, about 3 % absorption was observed within 48 hours, corresponding to about 1 % after 8 hours of exposure (ECHA web site - Information on chemicals. - Registered substances, URL of study:http://apps.echa.europa.eu/registered/data/dossiers/).
Additional evidence of the limitation of percutaneous absorption arises from characteristics of polyaromatic hydrocarbons: It was estimated from results of experimental in-vivo and in-vitro studies that less than 5 % was absorbable through human skin in vivo during 8 hours from a mixture containing among others naphthalene, methylnaphthalene as well as three- and four-ring aromatics (Creosote Council III Inc./USA, not published).
These data allow to conclude that percutaneous absorption of alkylation and transalkylation products of biphenyl with propene will be of the same order.
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