Registration Dossier
Registration Dossier
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EC number: 413-910-1 | CAS number: 1467668-33-2 LUPEROX 610-E-35; LUPEROX 610-E-50; LUPEROX 610-EN-50; LUPEROX 610-M-50; LUPERSOL 610; LUPERSOL 610-M-50
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
EC20-56 days (earthworm reproduction) of 1.752 mg/kg dw for 3-hydroxy-1,1-dimethylbutyl 2-ethyl-2-methylheptaneperoxoate has been measured.
Key value for chemical safety assessment
Additional information
Adult earthworms of the species Eisenia fetida were used in a earthworm reproduction test according to OECD 222 and GLP requirements (Odemer, 2015).
Exposure to 3-hydroxy-1,1-dimethylbutyl 2-ethyl-2-methylheptaneperoxoate of earthworms to treated soil for four weeks with mortality assessment and subsequent counting of offspring (number of juveniles + cocoons) after an additional four weeks of exposure was carried out. The Study consisted of seven treatments: One control, five test item concentrations (3.2, 10, 32, 100 and 320 mg active ingredient (a.i.) test item/kg dry soil) and one reference item (Carbendazim).
The validity criteria of the test were fulfilled.
After 56 days of exposure to 3-hydroxy-1,1-dimethylbutyl 2-ethyl-2-methylheptaneperoxoate, the EC20 and EC50 calculated for earthworm reproduction (juveniles) were determined to be 1.752 and 12.085 mg a.i. test item/kg dry soil, respectively (corresponding to 3.5 and 23.8 mg test item/L, respectively).
It was not possible to extrapolate an EC10 for earthworm reproduction related to the results obtained. Therefore the EC20 has been used as the key value for this long-term study. Indeed, as indicated in the Table R.10 -1 Chapter R.10 of REACH guidance (May 2008 version), ECx where x is a low effect percentile (e.g. 5 -20%) is recommended to express long-term effects.
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