Registration Dossier
Registration Dossier
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EC number: 200-533-0 | CAS number: 62-44-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
See also attached the chemical class information document. - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- The ECOSAR User Manual, ECOSAR. A Computer Program for Estimating the Ecotoxicity of Industrial Chemicals (EPA-748-R-93-002). Estimating Toxicity of Industrial Chemicals to Aquatic Organisms Using Structure Activity Relationships (EPA-748-R-93-001).
ECOSAR v1.11 Methodology Document.
ECOSAR v1.11 Operation Manual. - Specific details on test material used for the study:
- SMILES: CC(=O)Nc1ccc(OCC)cc1
- Test organisms (species):
- other: green algae
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 105.084 mg/L
- Nominal / measured:
- estimated
- Remarks on result:
- other: QSAR predicted value (Neutral organic SAR)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.693 mg/L
- Nominal / measured:
- estimated
- Remarks on result:
- other: QSAR predicted value (Amides class)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The algae 96-h EC50 for the test substance was predicted to be 2.693 mg/L (EPI-Suite, ECOSAR v1.11, lower value between class-specific (amides) and neutral organic SAR estimations).
- Executive summary:
The toxicity to aquatic algae of the test substance was determined by using EPI-Suite, ECOSAR v1.11. The algae 96-h EC50 for the test substance was predicted to be 2.693 mg/L based on class-specific estimation (amides) and 105.084 mg/L based on Neutral Organic SAR.
Reference
ECOSAR v1.11 predicted that the test substance has a 96 h-EC50 to algae of 2.693 mg/L based on class-specific estimation (amides-acid) and 105.084 mg/L based on Neutral Organic SAR.
Description of key information
Key Study: Data from EPI-Suite, EPA (USA) / ECOSAR v1.11. The algae 96-h EC50 for the test substance was predicted to be 2.693 mg/L based on class-specific estimation (amides) and 105.084 mg/L based on Neutral Organic SAR.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 2.693 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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