Registration Dossier
Registration Dossier
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EC number: 200-533-0 | CAS number: 62-44-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- other: Data from peer reviewed handbook
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- No data on test method
- GLP compliance:
- not specified
- Key result
- Water solubility:
- 766 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not specified
- Conclusions:
- Phenacetin is soluble in water (766 mg/L at 25ºC)
- Executive summary:
According to the peer reviewed handbook Solubilities Of Organic Compounds (1941), Phenacetin is soluble in water (766 mg/L)
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M. P.H. Howard and R.S. Boethling. 1996. Improved method for estimating water solubility from octanol/water partition coefficient. Environ. Toxicol. Chem. 15: 100-106.
- Specific details on test material used for the study:
- SMILES: CC(=O)Nc1ccc(OCC)cc1
- Water solubility:
- 2 485 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: QSAR predicted value
- Conclusions:
- The calculated water solubility is 2485 mg/L at 25ºC (EPI-Suite, EPA USA/WSKOW v1.43).
- Executive summary:
The calculated water solublity at 25ºC of the test substance is 2485 mg/L (EPI-Suite, EPA USA/WSKOW v1.43).
- Endpoint:
- water solubility
- Type of information:
- other: Data from peer reviewed handbook
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- No data on test method
- GLP compliance:
- not specified
- Type of method:
- other: Not specified
- Key result
- Remarks on result:
- other: slightly soluble in water
- Conclusions:
- Phenacetin is slightly soluble in water.
- Executive summary:
According to the peer reviewed handbook Hawley's Condensed chemical dictionary (2016), Phenacetin is slightly soluble in water
Referenceopen allclose all
WSKOW predicted that the test substance has a water solubility of 2485 mg/L at 25ºC.
Description of key information
Weight of evidence: According to the peer reviewed handbook Hawley's Condensed chemical dictionary (2016), phenacetin is slighly soluble in water
Weight of evidence: According to peer reviewed handbook Solubilities of Organic Compounds phenacetin has a solubility in water of 766 mg/L
Weight of evidence: According to (Q)SAR model, phenacetin has a water solubility of 2485 mg/L (25ºC)
Key value for chemical safety assessment
- Water solubility:
- 766 mg/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
