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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- January 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1,6-anhydro-β-D-glucose
- EC Number:
- 207-855-0
- EC Name:
- 1,6-anhydro-β-D-glucose
- Cas Number:
- 498-07-7
- Molecular formula:
- C6H10O5
- IUPAC Name:
- (1R,2S,3S,4R,5R)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
- Reference substance name:
- Glycollaldehyde
- EC Number:
- 205-484-9
- EC Name:
- Glycollaldehyde
- Cas Number:
- 141-46-8
- Molecular formula:
- C2H4O2
- IUPAC Name:
- 2-hydroxyacetaldehyde
- Reference substance name:
- Organic acids
- IUPAC Name:
- Organic acids
- Reference substance name:
- Ketones
- IUPAC Name:
- Ketones
- Reference substance name:
- Phenols
- IUPAC Name:
- Phenols
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Reference substance name:
- Oligomers of sugars and anhydrosugars
- IUPAC Name:
- Oligomers of sugars and anhydrosugars
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Results and discussion
Water solubilityopen allclose all
- Key result
- Water solubility:
- 7.32 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 10 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 6
- Key result
- Water solubility:
- 960 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1 003 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 6
- Details on results:
- A strong dependency of the solubility on the amount of the test item (nominal load) was perceived in the flasks 1 – 6.
As the solubility was dependent on the nominal concentration, no exact value for the solubility of the test item in water can be stated. Dependency of the pH value on the amount of the test item (nominal load) was perceived in the main test. Therefore the concentration of the test item in water is reported as a range: 7.32-960mg/L at 20.0°C.
Any other information on results incl. tables
Measurements during Equilibration
Day |
Flask |
Temperature [°C] |
pH* |
Concentration DOC Mean |
Conc. DOC – blank [mg/L] |
Conc. test item |
Difference [%] |
1 |
1A |
20.0 |
5-6 |
221 |
221 |
453 |
- |
2 |
1B |
20.0 |
5-6 |
205 |
205 |
422 |
-7.1 |
3 |
1C |
20.0 |
5-6 |
231 |
231 |
475 |
12.7 |
3 |
blank |
20.0 |
6 |
0.25 |
- |
- |
- |
The measured value in the blank flask was subtracted from the measured value in the flasks 1A – 1C.
After the analysis of the sample of day 3, the plateau was considered as reached.
Measurements at Plateau
Flask |
pH* |
Concentration DOC Mean [mg/L] |
Conc. DOC – blank [mg/L] |
Conc. test item |
2 |
6.16 |
3.82 |
3.57 |
7.32 |
3 |
5.04 |
20.3 |
20.2 |
41.1 |
4 |
4.57 |
45.2 |
44.8 |
92.0 |
5 |
3.68 |
381 |
382 |
782 |
6 |
3.70 |
468 |
468 |
960 |
*measured via calibrated pH meter
The measured value in the blank flask 0.25 mg/L was subtracted from the measured value in the flasks 2 – 6.
Temperature was measured with 20.0 °C.
Results
Flask |
Measured Conc. Test Item [mg/L] |
Nominal Conc. Test Item [mg/L] |
Dissolved Part [%] |
2 |
7.32 |
10 |
72.5 |
3 |
41.1 |
50 |
82.3 |
4 |
92.0 |
101 |
91.5 |
1* |
450 |
501 |
89.7 |
5 |
781 |
754 |
103.6 |
6 |
960 |
1003 |
95.7 |
*mean value of flasks 1A – 1C
Conclusion
As solubility was dependent on nominal concentration, no exact value for the solubility of the test item in water can be stated. The solubility range for the tested nominal concentration 10 – 1003 mg/L is 7.32 – 960 mg/L at 20.0 ± 0.5 °C (7.32 – 960 kg/m3in SI units), corresponding to 72.5 – 103.6 % of the test item relating to the nominal concentration of the test item.
Applicant's summary and conclusion
- Conclusions:
- The water solubility was found to be dependent on the nominal concentration. Therefore, the solubility range for the tested nominal concentration 10 – 1003 mg/L is 7.32 – 960 mg/L at 20.0 ± 0.5 °C, corresponding to 72.5 – 103.6 % of the test item relating to the nominal concentration of the test item.
- Executive summary:
The solubility of the test item in water was determined, according to OECD 105, by measurement of DOC concentration in the filtrated test solutions using TOC analyser.
During pre-tests for development of a specific analytical method several marker component candidates were tested for quantification of this UVCB substance via LC/MS/MS analysis. As the water solubility of components in UVCB substances can differ substantially, it was considered inadequate to base the water solubility of the mixture on a number of specific components because no information on the solubility of the remaining components is possible.
Therefore, the determination of total organic carbon was favored, because the solubility of the sum of all components is recorded and thus more meaningful information is generated.
As the test item is a UVCB substance, six different loading rates of the test item were chosen to study the effect of the loading rate on the measured water solubility: 10, 50, 100, 500, 750 and 1000 mg/L. Three flasks (1A – 1C) with the same loading rate (500 mg/L) were used during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h) and 2 – 6) were set onto the shaking apparatus immediately and shaking at 150 rpm was started. After 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature. Then, flasks 1A – 1C were removed from the shaker, tempered at 20.0 ± 0.5 °C, samples were taken, membrane filtered and analysed for DOC via TOC analyser.
Because of a difference of less than 15 % in the concentrations on days 2 and 3 and no upward tendency in the last three values, the test was finished. The final measurement was performed as determination from flasks 2 – 6. DOC was measured via TOC analyser in the saturated aqueous solutions. The pH value in the flasks 2 – 6 lay in the range of 3.70 – 6.16.
No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles were present.
A strong dependency of the solubility on the amount of the test item (nominal load) was per-ceived in the flasks 1 – 6.
As the solubility was dependent on the nominal concentration, no exact value for the solu-bility of the test item in water can be stated. Dependency of the pH value on the amount of the test item (nominal load) was perceived in the main test.
Therefore, the concentration of the test item in water was stated as
7.32 – 960 mg/L at 20.0 ± 0.5 °C
7.32 – 960 * 10-3kg/m3(SI units)
for the following nominal concentration range of the test item in water: 10 – 1003 mg/L, corresponding to a dissolved part of 92.6 ± 7.9 %of the test item (mean value) relating to the nominal concentration of the test item.
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