Registration Dossier
Registration Dossier
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EC number: 418-240-3 | CAS number: 74401-04-0 N-METHYL-4-(P-FORMYLSTYRYL)-PYRIDINIUM METHYLSULFATE; SBQ; SBQ-SALZ
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Non mutagenic with and without metabolic activation (Ames test)
Non mutagenic with and without metabolic activation (Chromosome aberration test)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The genotoxicity potential of the test substance was evaluated in vitro in a bacterial reverse mutation assay and in a chromosome aberration study in human lymphocytes. The Ames study was performed with and without metabolic activation on the S. typhimurium TA1535, TA1537, TA1538, TA98 and TA100 strains at concentrations in the range 50 - 5000 μg/plate. The chromosome aberration study was performed at concentrations in the range 78.1-480 μg/ml with metabolic activation and 20-156.25 μg/ml without metabolic activation.
In both studies, the substance was found as non-mutagenic with and without metabolic activation.
Justification for classification or non-classification
The substance did not induce genetic toxicity both in the Ames study and in the chromosome aberration study. Therefore, the substance is not classified for mutagenicity according to the CLP Regulation (EC) No.1272/2008.
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