Registration Dossier
Registration Dossier
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EC number: 418-240-3 | CAS number: 74401-04-0 N-METHYL-4-(P-FORMYLSTYRYL)-PYRIDINIUM METHYLSULFATE; SBQ; SBQ-SALZ
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-methyl-4-(p-formylstyryl)pyridinium methylsulfate
- EC Number:
- 418-240-3
- EC Name:
- N-methyl-4-(p-formylstyryl)pyridinium methylsulfate
- Cas Number:
- 74401-04-0
- Molecular formula:
- C16H17NO5S
- IUPAC Name:
- 4-[2-(4-formylphenyl)ethenyl]-1-methylpyridin-1-ium methyl sulfate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: distilled water
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Five
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occured during the study
- Clinical signs:
- other: No signs of toxicity were observed.
- Gross pathology:
- No treatment-related macroscopic findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: The test substance is not classified as harmful or toxic according to the CLP Regulation (EC) No. 1272/2008
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
The acute oral toxicity of the test substance was evaluated in rats in a limit test according to the EU method B.1 (92/69/EEC) and in compliance with GLP. Five animals per sex were dosed at 2000 mg/Kg bw. No mortality occured and no clinical signs as well as no treatment-related macroscopic findings were observed. All animals showed expected gains in bodyweight over the study period.
LD50 > 2000 mg/kg bw
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