Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 418-240-3 | CAS number: 74401-04-0 N-METHYL-4-(P-FORMYLSTYRYL)-PYRIDINIUM METHYLSULFATE; SBQ; SBQ-SALZ
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- N-methyl-4-(p-formylstyryl)pyridinium methylsulfate
- EC Number:
- 418-240-3
- EC Name:
- N-methyl-4-(p-formylstyryl)pyridinium methylsulfate
- Cas Number:
- 74401-04-0
- Molecular formula:
- C16H17NO5S
- IUPAC Name:
- 4-[2-(4-formylphenyl)ethenyl]-1-methylpyridin-1-ium methyl sulfate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Substance applied to the skin moistened with water.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/Kg bw
- No. of animals per sex per dose:
- Five
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occured
- Clinical signs:
- other: No signs of toxicity were observed.
- Gross pathology:
- No treatment-related macroscopic findings were observed
- Other findings:
- No signs of toxicity were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: The test substance is not classified as harmful or toxic according to the CLP Regulation (EC) No. 1272/2008
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
The acute dermal toxicity of the test substance was evaluated in rats in a semiocclusive limit test according to the EU method B.3 (92/69/EEC) and in compliance with GLP. Five animals per sex were dosed at 2000 mg/Kg bw. No mortality occured and no clinical signs as well as no treatment-related macroscopic findings were observed.
LD50 was found to be > 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
