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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 23 SEPTEMBER 2019 to 16 JANUARY 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
OECD Guidelines for the Testing of Chemicals, Method No. 105, adopted 27Jul. 1995: "Water Solubility".
Comission Regulation (EU) No 260/2014 amending Regulation (CE) No 440/2008: Method A.6: "Water solubility", adopted 24 January 2014.
Deviations:
yes
Remarks:
These deviations were assessed by the study director on Jan. 17th, 2020
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile
EC Number:
274-126-1
EC Name:
1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile
Cas Number:
69808-32-8
Molecular formula:
C17H17ClN4O2
IUPAC Name:
1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile
Test material form:
solid: particulate/powder
Details on test material:
- State of aggregation: powder
- Particle size distribution: not determined
- Mass median aerodynamic diameter (MMAD): not determined
- Geometric standard deviation (GSD): not determined
- Shape of particles: not determined
- Surface area of particles: not determined
- Crystal structure: not determined
- Coating: none
- Surface properties: not determined
- Density: 1.3526 ± 0.0010 g/cm3 at 20.0 ± 0.2°C
- Moisture content: <0.5%
- Residual solvent: not detected
- Activation: none
- Stabilisation: none
- Other:

Results and discussion

Water solubility
Key result
Water solubility:
>= 5.74 - <= 6.98 µg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 g/L
Incubation duration:
ca. 1 h
Temp.:
20 °C
pH:
ca. 6
Remarks on result:
other: Demineralided water was used.
Details on results:
All samples showed good correspondence. Standard deviation within the samples as well as all over the plateau was very low. The difference of concentrations measured for both flow rates was determined as 11.27%, thus was below 30%, therefore independency of solubility and flow rate is given.
no observations arousing doubts concerning the accuracy of the results and the validity of the study were made.

Applicant's summary and conclusion

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